- Bioorthogonal imaging of Aurora Kinase A in live cells
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In living color: Aurora kinase A (AKA) was imaged in live cells using a bioorthogonal two-step reaction with a small molecule AKA inhibitor (see scheme) and a fluorescent reporter. The fluorescent molecule was localized to spindle poles and microtubules d
- Yang, Katherine S.,Budin, Ghyslain,Reiner, Thomas,Vinegoni, Claudio,Weissleder, Ralph
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supporting information; experimental part
p. 6598 - 6603
(2012/09/22)
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- Compounds and methods for inhibiting mitotic progression
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This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat
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Page/Page column 140
(2008/06/13)
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- 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
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Novel 6-substituted 4H-imidazo[1,2-a][1,4]benzodiazepines, the intermediate 5-substituted-2-(2-alkynylamino)-3H-1,4-benzodiazepines, pharmacologically acceptable acid addition salts thereof, and processes for their production. The compounds of this invention and the pharmacologically acceptable acid addition salts thereof are central nervous system depressants. They are useful as sedatives, hypnotics, tranquilizers, muscle relaxants and anticonvulsants, and also as feed additives for increasing growth rate and feed efficiency of livestock and poultry, milk production in the mammalian species and egg production in avian species.
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