Synthesis of 1,3-disubstituted symmetrical/unsymmetrical ureas via Cs2CO3-catalyzed transamination of ethylene carbonate and primary amines
Cs2CO3-catalyzed transamination of primary amines and ethylene carbonate proceeds to form 1,3-disubstituted symmetrical/unsymmetrical ureas in excellent yields. The effect of different reaction parameters such as influences of bases, temperature, and reaction time were investigated for the title reaction.
Jagtap, Sachin R.,Patil, Yogesh P.,Panda, Anil G.,Bhanage, Bhalchandra M.
experimental part
p. 2093 - 2100
(2009/10/17)
Synthesis of 1-Hydroxyalkyl-3-Substituted Ureas and Thioureas, Substrates for Alcohol Dehydrogenase
A series of 1-(2-hydroxyethyl)- and 1-(3-hydroxyethyl)-3-substituted ureas and thioureas were synthesized. 1-(3-Hydroxyethyl)-3-acylthioureas were shown to be specific substrates for alcohol dehydrogenase in vitro.