- Design, synthesis, molecular docking, density functional theory and antimicrobial studies of some novel benzoxazole derivatives as structural bioisosteres of nucleotides
-
A series of some novel 2-(p-tert-butylphenyl)-5-(3-substituted-propionamido)benzoxazole derivatives have been designed, synthesized, evaluated for antimicrobial activity and have performed molecular docking studies against penicillin-binding protein 4 (PBP4) and active and allosteric site of PBP2a; were calculated some theoretical quantum parameters and absorption, distribution, metabolism and excretion (ADME) descriptors. B9 acted at minimum inhibitory concentration (MIC) = 8 μg/mL against S. aureus, E. faecalis and their drug-resistant isolates and also formed with GLU145 (1.74 ?) and ILE144 (1.89 ?) two hydrogen bonds at allosteric site of PBP2a with Glide emodel score: ?42.168. ΔE of compound B9 had moderate value of all compounds with 0.14742. (Figure presented.) Communicated by Ramaswamy H. Sarma.
- Erol, Meryem,Celik, Ismail,Temiz-Arpaci, Ozlem,Kaynak-Onurdag, Fatma,Okten, Suzan
-
-
Read Online
- Reactive, spectroscopic and antimicrobial assessments of 5-[(4-methylphenyl) acetamido]-2-(4-tert-butylphenyl)benzoxazole: Combined experimental and computational study
-
The synthesis, FT-IR, FT-Raman and NMR spectral analysis of an antimicrobial active benzoxazole derivative, 5-[(4-methylphenyl)acetamido]-2-(4-tert-butylphenyl) benzoxazole (MPATB) is reported. The localization of HOMO, LUMO plots in the title compound ov
- Mary, Y. Sheena,Alzoman, Nourah Z.,Menon, Vidya V.,Al-Abdullah, Ebtehal S.,El-Emam, Ali A.,Panicker, C. Yohannan,Temiz-Arpaci, Ozlem,Armakovi?, Stevan,Armakovi?, Sanja J.,Van Alsenoy
-
-
Read Online
- Synthesis, vibrational spectroscopic investigations, molecular docking, antibacterial studies and molecular dynamics study of 5-[(4-nitrophenyl)acetamido]-2-(4-tert-butylphenyl)benzoxazole
-
Antimicrobial active 5-[(4-nitrophenyl)acetamido]-2-(4-tert-butylphenyl)benzoxazole (NATPB) was synthesized and observed IR, Raman bands are compared with the theoretically predicted wave numbers. In the IR spectrum the NH stretching wave number splits in
- Sheena Mary,Al-Shehri, Mona M.,Jalaja,Al-Omary, Fatmah A.M.,El-Emam, Ali A.,Yohannan Panicker,Armakovi?, Stevan,Armakovi?, Sanja J.,Temiz-Arpaci, Ozlem,Van Alsenoy
-
-
Read Online
- Synthesis and antimicrobial evaluation of novel 5-substituted-2-(p-tert-butylphenyl)benzoxazoles
-
In the present study, a series of nine novel 5-substituted-2-(p-tert-butylphenyl)benzoxazole derivatives have been synthesized and their structures confirmed by spectral techniques and also tested for their antimicrobial activities. The minimum inhibitory
- Ta?ci, Meryem,Terniz-Arpaci, Ozlem,Kaynak-Onurdag, Fatma,Okten, Suzan
-
p. 385 - 389
(2019/05/21)
-
- Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
-
Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
- -
-
Page/Page column 12
(2016/10/17)
-
- ANTICANCER SUPPLEMENT AGENT INCLUDING BENZO[D]OXAZOL DERIVATIVE AS EFFECTIVE INGREDIENT
-
Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
- -
-
Paragraph 0076; 0077; 0078
(2015/07/22)
-
- Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles
-
The synthesis and antimicrobial activity of a new series of 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazole derivatives 3-12 were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positi
- Alper-Hayta, Sabiha,Arisoy, Mustafa,Temiz-Arpaci, Oezlem,Yildiz, Ilkay,Aki, Esin,Oezkan, Semiha,Kaynak, Fatma
-
p. 2568 - 2578
(2008/12/23)
-
- Synthesis and antimicrobial activity of some 5-[2-(morpholin-4-yl) acetamido] and/or 5-[2-(4-substituted piperazin-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazoles
-
In this study, a series of twelve novel 5-[2-(morpholin-4-yl)acetamido] and/or 5-[2-(4-substituted piperazine-1-yl)acetamido]-2-(p-substituted phenyl)benzoxazole derivatives have been synthesized and their structures were confirmed by IR, 1H NM
- Temiz-Arpaci, Oezlem,Oezdemir, Aliye,Yalcin, Ismail,Yildiz, Ilkay,Aki-Sener, Esin,Altanlar, Nurten
-
p. 105 - 111
(2007/10/03)
-
- SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS
-
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.
- -
-
Page/Page column 133
(2010/02/14)
-