- Superalkali-Alkalide Interactions and Ion Pairing in Low-Polarity Solvents
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The nature of anionic alkali metals in solution is traditionally thought to be "gaslike"and unperturbed. In contrast to this noninteracting picture, we present experimental and computational data herein that support ion pairing in alkalide solutions. Concentration dependent ionic conductivity, dielectric spectroscopy, and neutron scattering results are consistent with the presence of superalkali-alkalide ion pairs in solution, whose stability and properties have been further investigated by DFT calculations. Our temperature dependent alkali metal NMR measurements reveal that the dynamics of the alkalide species is both reversible and thermally activated suggesting a complicated exchange process for the ion paired species. The results of this study go beyond a picture of alkalides being a "gaslike"anion in solution and highlight the significance of the interaction of the alkalide with its complex countercation (superalkali).
- Riedel, René,Seel, Andrew G.,Malko, Daniel,Miller, Daniel P.,Sperling, Brendan T.,Choi, Heungjae,Headen, Thomas F.,Zurek, Eva,Porch, Adrian,Kucernak, Anthony,Pyper, Nicholas C.,Edwards, Peter P.,Barrett, Anthony G. M.
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supporting information
p. 3934 - 3943
(2021/04/06)
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- 225Ac-HEHA and related compounds, methods of synthesis and methods of use
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The present invention provides an α-particle-emitting radioisotope chelation complex comprising225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N′″,N″″,N′″″-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional225Ac-HEHA. The bifunctional HEHA and the bifunctional225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from225Ac, a method of decontaminating a person who has been externally contaminated with225Ac, and a method of detoxifying a person who has internalized225Ac.
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Page column 14
(2010/11/30)
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- MACROHETEROCYCLES. 15.* SYNTHESIS OF MACROCYCLIC POLYAMINES IN A BIPHASIC SYSTEM
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Macrocyclic polyamines are conveniently synthesized by condensation of bissulfonamides with ditosylates or dibromides of glycols in the biphasic system toluene(xylene)-aqueous sodium hydroxide.
- Luk'yanenko, N. G.,Basok, S. S.,Filonova, L. K.,Kulikov, N. V.,Pastushok, V. N.
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p. 346 - 349
(2007/10/02)
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- Macrocyclic polyamines
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Macrocyclic polyamines containing 3-7 nitrogen atoms in the ring and destablized to complex formation by (1) an asymmetric ring and/or (2) provision of nitrogen atoms in excess of that required for complex formation are described. The compounds can be used to extract metal ions from solution. The metal complexes are thermally activated curing agents for epoxy resins.
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