- Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT1 melatoninergic ligands
-
Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and various aryl units are linked via a linear alkyl chain through the methoxy group. The compounds were tested for their actions at melatonin receptors. Several of these liga
- Mésangeau, Christophe,Pérès, Basile,Descamps-Fran?ois, Carole,Chavatte, Philippe,Audinot, Valérie,Coumailleau, Sophie,Boutin, Jean A.,Delagrange, Philippe,Bennejean, Caroline,Renard, Pierre,Caignard, Daniel H.,Berthelot, Pascal,Yous, Sa?d
-
scheme or table
p. 3426 - 3436
(2010/11/04)
-
- Pictet-Spengler heterocyclizations via microwave-assisted degradation of DMSO
-
For the first time the ability of DMSO to decompose rapidly under microwaves was explored in order to perform heterocyclizations in good conditions. This modified Pictet-Spengler reaction allowed, in this case, the synthesis of rigidified melatonin analog
- Mésangeau, Christophe,Yous, Sa?d,Pérès, Basile,Lesieur, Daniel,Besson, Thierry
-
p. 2465 - 2468
(2007/10/03)
-
- Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT3
-
The aim of this study was to synthesize selective ligands for melatoninergic subtype receptors that could elucidate the physiological role of melatonin (N-acetyl-5-methoxytryptamine, 1). So, we first investigated the role of a nitro substituent in the 4-,
- Leclerc, Véronique,Yous, Sa?d,Delagrange, Philippe,Boutin, Jean A.,Renard, Pierre,Lesieur, Daniel
-
p. 1853 - 1859
(2007/10/03)
-
- Substituted dimeric compounds
-
The invention relates to compound of formula (I): A—G1—Cy—G2—Cy′—G3—B??(I) wherein: A represents a grouping NR1C(Q)R2, C(Q)NR2R3or NR1C(Q)NR2R3, B represents a grouping NR1C(Q)R2, NR1C(Q)NR2R3, C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2or NR2R3, G1and G3represent an optionally substituted alkylene chain, Cy and Cy′, which are different, represent a ring structure or G2represents a chain and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
- -
-
-