The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.
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(2008/06/13)
REACTION OF 1,2-ANHYDRO-3,4:5,6-DI-O-ISOPROPYLIDENE-1-C-NITRO-D-MANNITOL WITH POTASSIUM HYDROGENEFLUORIDE IN ETHYLENE GLYCOL: A SYNTHESIS OF 2-DEOXY-2-FLUORO-D-GLUCOSE
The reaction of 1,2-anhydro-3,4:4,5-di-O-isopropylidene-1-C-nitro-D-mannitol (2) with potassium hydrogenfluoride in ethylene glycol under anhydrous conditions provides a route to 2-deoxy-2-fluoro-D-glucose, the (18)F-labeled analog of which is an important radiopharmaceutical of use in medical imaging.The reaction is accompained to a minor extent by epimerization at C-2 of the initially formed fluoro aldehyde and also results in attack by solvent at C-2 in 2.
Szarek, Walter A.,Hay, George W.,Doboszewski, Bogdan,Perlmutter, Milton M.
p. 107 - 118
(2007/10/02)
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