- Preparation method of nitro compound
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The invention discloses a preparation method of a nitro compound, which comprises: carrying out a reaction on a compound 1A and a compound 1B to obtain a compound 2A; and reacting the compound 2A witha nitration reagent to obtain a nitro compound crude product, and purifying to obtain a nitro compound fine product. According to the method, a reagent with low price is used as an initial raw material to prepare the final product through two-step reaction, wherein the reaction condition of each step is mild, the yield of the obtained nitro compound is high, and the cost can be greatly reduced.
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Paragraph 0046-0048
(2021/03/13)
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- NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
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Described herein are neuroactive steroids of the Formula (I): (I) or a pharmaceutically acceptable salt thereof; wherein R1, R2, Ra, G, X, Y, Z, and n are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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Paragraph 469
(2016/09/15)
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- Direct transformation of dialkyl sulfates into alkyllithium reagents by a naphthalene-catalysed lithiation
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The lithiation of primary and secondary dialkyl sufates with an excess of lithium powder in the presence of a catalytic amount of naphthalene (4 mol %) in THF at -78°C leads to the corresponding alkyllithium reagents (1:2 molar ratio) which react with different electrophiles, mainly carbonyl compounds, to yield after hydrolysis, the expected coupling products. This methodology represents an indirect way to transform alcohols into organolithium compounds through the corresponding dialkyl sulfates. When the same procedure is applied to five or six member cyclic sulfates (derived from 1,2- or 1,3-diols) only products arising from a β- or γ-elimination process (giving olefins or cyclopropanes), respectively, are obtained.
- Guijarro, David,Guillena, Gabricia,Mancheno, Balbino,Yus, Miguel
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p. 3427 - 3436
(2007/10/02)
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- Reactions of Group V Metal Compounds with Sulfur Trioxide
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Trialkylphosphines react with equimolar amounts of sulfuric trioxide to form the 1:1 adducts R3P(1+)-SO3(1-).Trialkylarsines and -stibines undergo sulfur trioxide insertion reaction across the metal-carbon bond to give the trisulfonates of the metal M(OSO2R)3 (M=As,Sb).The reactions of trialkyl phosphites, with sulfur trioxide yield trialkyl phosphonates, trialkyl thiophosates, dialkyl alkylphosphonates, dialkyl sulfates, and polymers which contain phosphorus atoms.The reactions of trialkoxyarsines and -stibines result in the insertion of sulfur trioxide across the metal-oxygen bond to form the alkoxymetal alkylsulfates (RO)3-nM(OSO3R)n (M=As,Sb; n=1,2,3) depending on the stoichiometric ratios of the reagents used.Pyrolysis of the metal sulfates gives dialkyl sulfates and undistillable residues containing the metals.
- Ando, Fumio,Koketsu, Jugo,Ishii, Yoshio
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p. 3495 - 3499
(2007/10/02)
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