Synthesis of new anthracycline derivatives containing pyruvic, aspartic, or N-acetylaspartic acid molecule
The new anthracycline analogues (2-10) as potential anti-cancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a
Rho, Young S.,Park, Siho,Kim, Wan-Joong,Kim, Gyuil,Yoo, Dong Jin,Kang, Heun-Soo,Chung, Soon-Ryang
NEW PEPTIDE-LINKED ESTER PRODRUGS ACTIVATED BY PROSTATE-SPECIFIC ANTIGEN
The present disclosure is directed to a series of target-selective chemotherapeutic ester prodrugs comprising PSA-cleavable peptides that promote the delivery of free doxorubicin and other chemotherapeutic agents into the prostate and/or prostate tumors with greater efficiency.
-
Paragraph 21; 87-88; 106
(2018/08/26)
More Articles about upstream products of 29742-67-4