Peptide Bond Formation via Nα-Protected Diacyldiselenides
Abstract: A simple, straightforward, for the peptide bond formation employing corresponding carboxylic acids and amines derived from amino acids via Nα-protected diacyldiselenide is delineated. The key step of the synthesis is the in situ gener
Vathsala,Roopesh Kumar,Sagar,Mahesh,Venkata Ramana,Sureshbabu, Vommina V.
p. 653 - 658
(2018/04/26)
Amide and Peptide Bond Formation in Water at Room Temperature
A general and environmentally responsible method for the formation of amide/peptide bonds in an aqueous micellar medium is described. Use of uronium salt (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium hexafluorophosphate (COMU) as a coupling reagent, 2,6-lutidine, and TPGS-750-M represents mild conditions associated with these valuable types of couplings. The aqueous reaction medium is recyclable leading to low E Factors.
Gabriel, Christopher M.,Keener, Megan,Gallou, Fabrice,Lipshutz, Bruce H.
supporting information
p. 3968 - 3971
(2015/09/01)
Phosphonyldipeptides useful in the treatment of cardiovascular diseases
Compounds of formula (II) STR1 wherein R is a biphenyl group optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl or thioalkyl groups having from 1 to 6 carbon atoms in the
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(2008/06/13)
Selectivity and Specificity in Substrate Binding to Proteases: Novel Hydrolytic Reactions Catalysed by α-Chymotrypsin Suspended in Organic Solvents with Low Water Content and Mediated by Ammonium Hydrogen Carbonate
α-Chymotrypsin suspended in organic solvents with low water content catalysed hydrolytic reactions in the presence of ammonium hydrogen carbonate.Molecular modelling studies were carried out and structure-reactivity relationships were established by studying the hydrolysis of amino acid derivatives and analogues.The enzyme was found to be stereoselective with respect to the hydrolysis of L-amino acid derivatives, but no stereoselectivity was observed when α-hydroxy esters were used as substrates.A general procedure for the resolution of aromatic amino acid esters is given.The results are interpreted in terms of molecular modelling based on X-ray crystallographic data and literature data.
Ricca, Jean-Marc,Crout, David H. G.
p. 1225 - 1234
(2007/10/02)
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