- Preparation method of 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol
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The invention discloses a preparation method of 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol, which comprises the following steps: dissolving isobutyryl chloride in a first organic solvent, adding triethylamine and zinc powder while stirring, heating to reflux, reacting, cooling, filtering, washing, and carrying out reduced pressure distillation to obtain a distillation substrate; and dissolving the distillation substrate in a second organic solvent, cooling, filtering, introducing hydrogen under the action of a catalyst, and carrying out a reaction to obtain the product. According to the method, on the basis of the process of the BASF company, after triethylamine hydrochloride is formed by triethylamine serving as an acid-binding agent, triethylamine is released from the triethylamine hydrochloride by using proper metal, so that the triethylamine serving as the acid-binding agent can be recycled, and the triethylamine only plays a role of a bridge in a system; through continuous exchange and circulation of a small amount of triethylamine, the reaction is carried out until the reaction is complete.
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Paragraph 0014; 0027; 00289-0030; 0032-0033; 0035-0036; 0038
(2021/03/11)
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- Tetramethylcyclobutanedione and tetramethylcyclobutane diol Method for manufacturing the same
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The invention provides tetramethylcyclobutanedione and tetramethylcyclobutane diol, and a manufacturing method thereof. The present invention provides the following method. 2, 2, 4, 4 - Tetramethylcyclobutane -1, 3 - diketones can be easily produced by carrying out the dimerization reaction of the dimethylketene in a solvent suitable for the actual production (reaction time) by easily treating and general low boiling solvent in the production process. The dimerization reaction of the dimethyl ketene can be accelerated, and the time required for solvent removal can be shortened as compared with the high-boiling solvent. Compared with the prior art, the manufacturing can be performed in a short time.
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Paragraph 0075-0078
(2021/09/29)
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- PROCESS FOR PREPARING 2,2,4,4-TETRAMETHYL-1,3-CYCLOBUTANEDIOL
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Disclosed is a method for preparing 2,2,4,4-tetramethyl-1,3-cyclobutanediol, which prepares (E) 2,2,4,4-tetramethyl-1,3-cyclobutanediol (CBDO) which is a final material by sequentially going through (A) methacrylic acid (MAA) as a raw material, and (B) isobutyric acid (IBA), (C) isobutyric anhydride (IBAN), and (D) 2,2,4,4-tetramethyl-1,3-cyclobutanedione (CBDK) as an intermediate. According to the present invention, the method for preparing 2,2,4,4-tetramethyl-1,3-cyclobutanediol which is economical and eco-friendly by optimizing preparation steps and maximizing the efficiency is provided.COPYRIGHT KIPO 2019
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Paragraph 0160-0173
(2019/10/08)
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- PROCESS FOR PREPARING 2,2,4,4-TETRAMETHYL-1,3-CYCLOBUTANEDIOL
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The present invention refers to 2, 2, 4, 4 - tetramethyl - 1, 3 - cyclohexanedimethanol bhutan d this year a number bath method disclosure as follows. the method (A) meta acrylic acid (methacrylic acid, MAA) removed from the raw material (B) use as an intermediate in the mote [lik [lik] it buys [...] (isobutyric acid, IBA), 2, 2, 4, 4 - tetramethyl - 1, 3 - cyclohexanedimethanol [...] (C) dimethyl ketene (dimethyl Ketene, DMK) and (D) (2, 2, 4, 4 a-tetramethyl-a 1, 3 non-cyclobutanedione, CBDK) via a final material sequentially (E) 2, 2, 4, 4 - tetramethyl bhutan d this year cycle - 1, 3 - (2, 2, 4, 4 a-tetramethyl-a 1, 3 non-cyclobutanediol, CBDO) bath a number comprise substrate. According to the present invention number bath step optimization and a green protective environmental 2, 2, 4, 4 - tetramethyl - 1, 3 - cyclohexanedimethanol bhutan d this year through mirror number is encoded number bath method is highly lipophilic ball number. (by machine translation)
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Paragraph 0098-0110
(2019/10/22)
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- CATALYST AND METHOD FOR HYDROGENATION OF 1,3-CYCLOBUTANEDIKETONE COMPOUND
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Catalyst for hydrogenation of 1,3-cyclobutanediketone compound is provided, which includes a support and VIIIB group transition metal loaded thereon. The support includes a first oxide powder with a surface wrapped by a second oxide. The first oxide includes silicon oxide, aluminum oxide, zirconium oxide, titanium oxide, zinc oxide, or a combination thereof. The second oxide has a composition of MxAl(1-x)O(3-x)/2, M is alkaline earth metal, and x is from 0.3 to 0.7.
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Paragraph 0032
(2017/12/27)
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- Synthetic method of 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol
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The invention provides a synthetic method of 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol. The synthetic method is a highly selective conversion method of 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanedione into 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol. The synthetic method comprises the following steps: using 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanedione as a reaction raw material; and carrying out hydrogenation reaction of the 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanedione so as to generate 2, 2, 4, 4-tetramethyl-1, 3-cyclobutanediol. Catalysts utilized in the reaction comprise copper, zinc, aluminum and chromium elements. Weighed by weights of oxides of the copper, zinc, aluminum and chromium elements, weight of the copper oxide accounts for 40-70 parts of the total weight of the catalysts; weight of the zinc oxide accounts for 10-35 parts of the total weight of the catalysts; weight of the aluminum oxide accounts for 10-20 parts of the total weight of the catalysts; and weight of the chromium oxide accounts for 5-10 parts of the total weight of the catalysts. The synthetic method disclosed by the invention is simple in processes and relatively fewer in side effects.
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Paragraph 0074; 0075; 0077
(2017/04/03)
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- DERMATOLOGICAL COMPOSITIONS AND METHODS
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Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
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- Treatment of neurodegenerative diseases
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Disclosed are methods for increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage by administration of various compounds including alcohols, diols and/or triols and their analogues.
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- Treatment of diseases mediated by the nitric oxide/cGMP/protein kinase G pathway
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Disclosed are methods and compositions for stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway, by administration of various compounds including alcohols, diols and/or triols and their analogues.
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