An in vitro approach to potential methadone metabolic-inhibition interactions
Objective: The aim of this study was to assess the drug interaction potential of psychotropic medication on methadone N-demethylation using cDNA-expressed cytochrome P450 CYP enzymes. Methods: Methadone was incubated with various drugs (n = 10) and cDNA-e
Methadone pharmacotherapy is considered the standard for treatment of the pregnant heroin/opioid addict. One of the factors affecting the transfer kinetics of opioids across human placenta and their levels in the fetal circulation is their metabolism by t
Nanovskaya, Tatiana N.,Deshmukh, Sujal V.,Nekhayeva, Ilona A.,Zharikova, Olga L.,Hankins, Gary D.V.,Ahmed, Mahmoud S.
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
Methadone has become one of the most widely used drugs for opiate dependency treatment. This drug is extensively metabolized by the cytochrome P450 hepatic enzyme family in man, yielding an N-demethylated metabolite that cyclizes spontaneously into 2-ethy
Iribarne, Christelle,Berthou, Francois,Baird, Susan,Dreano, Yvonne,Picart, Daniel,Bail, Jean Pierre,Beaune, Philippe,Menez, Jean Francois