Efficient synthesis of tertiary amines from secondary amines
Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins.
Kurosu, Michio,Dey, Sevendu Sekhar,Crick, Dean C.
p. 4871 - 4875
(2007/10/03)
Solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation using a hydroxylamine linker
The solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmentation employing a hydroxylamine linker is described. The hydroxylamine linker is traceless, robust and versatile, allowing strong organometallic reagents to be used in the synthesis of diverse tertiary methylamines. (C) 2000 Elsevier Science Ltd.
Blaney,Grigg,Rankovic,Thoroughgood
p. 6635 - 6638
(2007/10/03)
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