From Azido Acids to Macrolactams and Macrolactones
A new method is reported for the conversion of azido acids into lactams, via thioester formation and in situ azide reduction and cyclisation under high-dilution conditions; since the quantitative conversion of macrolactams to macrolactones has been shown to be feasible, this results in an indirect, alternative macrolactonisation procedure.
LIPASE CATALYZED SYNTHESIS OF MACROCYCLIC LACTONES IN ORGANIC SOLVENTS
A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described.The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents.The procedure is also applicable to the synthesis of asymmetric lactones.
Makita, Atushi,Nihira, Takuya,Yamada, Yasuhiro
p. 805 - 808
(2007/10/02)
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