- Direct hydroxyethylation of amines by carbohydrates: Via ruthenium catalysis
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An efficient and halogen-free catalytic methodology for the synthesis of β-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields.
- Jia, Le,Makha, Mohamed,Du, Chen-Xia,Quan, Zheng-Jun,Wang, Xi-Cun,Li, Yuehui
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supporting information
p. 3127 - 3132
(2019/06/18)
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- New photosensitive methacrylate monomers with 4-aminoazobenzene type chromophore group
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Photosensitive methacrylate monomers, derivatives of azobenzene, were synthesized. The route of syntheses was based on coupling of diazonium salts of sulfathiazole, sulfomethoxazole, sulfadiazine, 4-aminobenzoic acid and 4-nitroaniline with N-alkyl-N-[2-(methacryloyloxy)ethyl]aniline. The trans?cis isomerization of the monomers in DMSO solution was investigated by UV-VIS spectroscopy recording their spectra during illumination and thermal recovery periods. It was found that except for nitro derivatives the yield of trans-cis isomerization was ca. 50% and that the reverse reaction was a result of thermal relaxation. The spectroscopic studies were accompanied by quantum chemical calculations.
- Janik,Kucharski,Kubainska,Lyko
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p. 241 - 252
(2007/10/03)
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- Novel N-Alkylation of Amines with Organocopper Reagents
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A mild and efficient method for the N-alkylation of amines is described, based on the oxidative coupling of lithium alkylcopper amide, which is derived from lithium dialkylcuprates and primary or secondary amines.The high chemospecificity of the method was demonstrated.
- Yamamoto, Hisashi,Maruoka, Keiji
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p. 2739 - 2740
(2007/10/02)
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