- Selective Zn2+ recognition of novel triazole Schiff-base derivatives bearing the coumarin group
-
Three novel triazole Schiff-bases derivatives bearing coumarin units have been synthesised from 3,5-diaryl-4-amino-1,2,4-triazole with three kinds of coumarin aldehydes. The UV.Vis absorption and fluorescence emission spectra of (E )-4-((3,5-diphenyl-4H-
- Wang, Wei,Qi, Shuai,Liu, Qing-Lei,Lei, Ya-Nan,Yuan, Wen-Jing,Gao, Yan
-
-
Read Online
- Synthesis and Fe3+ recognition of novel triazole Schiff-base derivatives bearing fluorogenic naphthalene and anthracene units
-
Novel triazole Schiff-bases derivatives have been synthesised from 3,5-diaryl-4-amino-1,2,4-triazole with naphthaldehyde and anthraldehyde. The emission spectrum of 3,5-diphenyl-4-(anthrylmethyleneamino)-1,2,4-triazole exhibited fluorescent quenching upon
- Wang, Wei,Yu, Xiaolong,Zhang, Qiang,Li, Mingzhu,Jiang, Xiaoyu,Liu, Qinglei,Gao, Yan
-
-
Read Online
- Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
-
In the past decade, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases has been in focus. In this direction, we here present the facile microwave assisted synthesis of some acyl hydrazides and triazoles, followed by their evaluation as protease inhibitors and inhibitory studies on cathepsin B and cathepsin H, two significant lysosomal cysteine proteases. The compounds were characterized by 1H NMR, 13C NMR, Mass and IR spectral data. The compounds which were found inhibitory to endogenous proteolysis in liver homogenate at pH 5.0 were further studied for determination of inhibition type and Ki values on purified cathepsin B and cathepsin H. The maximum inhibitory effect was exerted by 3-(3′-nitrophenyl)-5-(3′-nitrophenyl)-4-amino-1,2,4-triazoles (2c), 3-(4′-chlorophenyl)-5-(4′-chloro phenyl)-4-amino-1,2,4- triazoles (2h), 3-(3′-aminophenyl)-5-(3′-aminophenyl)-4-amino-1,2,4- triazoles (2i) and 4-methoxybenzohydrazide (1b).
- Raghav, Neera,Singh, Mamta
-
-
Read Online
- A study on the condensation reaction of aryl substituted 4-amine-1,2,4-triazole with benzaldehydes: Structures and spectroscopic properties of schiff bases and stable hemiaminals
-
A series of stable hemiaminals and Schiff bases containing 3,5-disubstituted 1,2,4-triazole derivatives were synthesized. The structure of the prepared compounds was confirmed by means of 1H NMR, 13C NMR, IR, MS and elemental analysi
- Wajda-Hermanowicz, Katarzyna,Pieni?zczak, Damian,Wróbel, Robert,Zatajska, Aleksandra,Ciunik, Zbigniew,Berski, S?awomir
-
p. 108 - 122
(2016/03/01)
-
- Synthesis and biological evaluation of some novel 3,5-disubstituted-1,2,4- triazole incorporated 2-mercaptobenzothiazoles
-
Several 2-mercaptobenzothiazole derivatives 5a-i containing 1,2,4-triazole moiety incorporating two additional substituents were synthesized. All the newly synthesized compounds were tested for in vitro activity against certain strains of bacteria such as Enterococcus faecalis, Bacillus coagulans, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. Compound 5a showed significant activity against the Gram-negative bacteria Escherichia coli. Compounds 5a-i were also screened for their antifungal activity against Candida albicans and compounds 5a, 5b, 5d and 5g displayed significant activity against this fungus. Some of these compounds were evaluated for their in vivo anti-inflammatory activity, acute toxicity and ulcerogenic actions. Tested compounds 5g and 5h showed significant anti-inflammatory activity and significant gastrointestinal protection compared to the standard drug diclofenac sodium. Molecular modeling studies of the synthesized compounds are presented.
- Azam, Mohammed Afzal,Suresh, Bhojraj,Srinivas, Naga,Sachdev, Sumit,Rajeshkumar, Raman
-
p. 739 - 748
(2013/02/22)
-
- Synthesis, extraction and antibacterial studies of some new bis-1,2,4-triazole derivatives part II
-
The treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole 3 with various bis-aldehydes resulted in the formation of bis-4-arylidenamino-3,5-diphenyl-4H- 1,2,4-triazoles (4a-d) derivatives. NaBH4 reduction of 4-arylidenamino derivatives of 1,2,4-t
- Guemruekcueoglu, Nurhan,Ugras, Serpil,Ugras, Halil Ibrahim,Cakir, Uemit
-
p. 359 - 367
(2012/10/07)
-
- Synthesis of new bis-1,2,4-triazole derivatives
-
A series of new 1,2/1,3-bis[o-(N-methylidenamino-3-aryl-5-phenyl-4H-1,2,4- triazole-4-yl)phenoxy]ethane/propane derivatives 4 were prepared in good yields by treatment of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 2 with certain bis-aldehydes 1. Compounds
- Bekircan, Olcay,Bektas, Hakan
-
p. 469 - 477
(2007/10/03)
-
- Synthesis of some 3,5-diphenyl-4H-1,2,4-triazole derivatives as antitumor agents
-
A series of 4-arylidenamino-4H-1,2,4-triazoles 2-14 and 4-(1-aryl)ethylidenamino-4H-1,2,4-triazoles 28-30 have been synthesized by the treatment of 4-amino-4H-1,2,4-triazole 1 with certain aldehydes and ketones. Compounds 2-14 and 28-30 have been reduced
- Bekircan, Olcay,Guemruekcueoglu, Nurhan
-
p. 2107 - 2113
(2007/10/03)
-
- A facile and solvent-free synthesis of 3,5 -disubstituted-4-amino-1,2,4-triazoles by reactions of aromatic nitriles with hydrazine
-
A variety of 3, 5-disubstituted-4-amino-1,2,4-triazoles were prepared by reactions of aromatic nitriles with hydrazine monohydrate. The structure of 3,5-diphenyl-4-amino-1,2,4-triazole was established by an X-ray analysis.
- Ikemi, Yukio,Hayashi, Naoto,Kakehi, Akikazu,Matsumoto, Kiyoshi
-
p. 439 - 442
(2007/10/03)
-
- High-throughput synthesis of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles from aldehydes using microwave
-
Symmetrically 3,5-substituted 4-amino-1,2,4-triazoles are quickly prepared from aromatic aldehydes via nitriles by two-step reactions without any separation under microwave irradiation for each several minutes.
- Koshima, Hideko,Hamada, Mitsuo,Tani, Makiko,Iwasaki, Shunsuke,Sato, Fumika
-
p. 2145 - 2148
(2007/10/03)
-
- Synthesis of 3,5-diaryl-4-benzylidene-amino-1,2,4-triazoles and 4-amino-3,5-diaryl-1,2,4-triazoles
-
A one-pot reaction leading to 3,5-diaryl-4-benzylideneamino-1,2,4-triazoles is described, the key step of which is the reaction of arenecarbohydrazonoyl chloride with benzylidenehydrazide. Compounds obtained in this way were hydrolyzed to 4-amino-3,5-diaryl-1,2,4-triazoles.
- Zielinski,Czardybon
-
p. 1107 - 1110
(2007/10/03)
-
- Accelerated synthesis of 3,5-disubstituted 4-amino-1,2,4-triazoles under microwave irradiation
-
A number of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles are quickly prepared by the reaction of aromatic nitriles on hydrazine dihydrochloride in the presence of an excess of hydrazine hydrate in ethylene glycol under microwave irradiation. (C
- Bentiss, Fouad,Lagrenée, Michel,Barbry, Didier
-
p. 1539 - 1541
(2007/10/03)
-
- A simple one step synthesis of new 3,5-disubstituted-4-amino-1,2,4- triazoles
-
A number of symmetrically 3,5-disubstituted 4-amino-1,2,4-triazoles have been prepared by the reaction of aromatic nitriles with hydrazine dihydrochloride or sulfate with an excess of hydrazine hydrate in ethylene or diethylene glycol under a nitrogen atm
- Bentiss,Lagrenee,Traisnel,Mernari,Elattari
-
p. 149 - 152
(2007/10/03)
-
