- Method for asymmetrically synthesizing norepinephrine bitartrate
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The invention discloses a preparation method for asymmetrically synthesizing norepinephrine bitartrate. The method is characterized by comprising the following steps: by using chloroacetyl catechol asa raw material, asymmetrically reducing carbonyl in the chloroacetyl catechol into hydroxyl, reacting with urotropine, hydrolyzing with hydrochloric acid to obtain R-norepinephrine, salifying rnorepinephrine and Ltartaric acid are salified to obtain norepinephrine bitartrate, wherein the total yield is larger than or equal to 86%, the ee value is larger than or equal to 95%, and the purity is larger than or equal to 99.6%. The method overcomes the defects in the prior art, and has the advantages that asymmetric reduction is adopted, so that the yield of norepinephrine bitartrate is increased,three wastes and the cost are reduced, and the method is suitable for industrial production.
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