cas 305370-84-7, 4-chloro-6-nitro-1,8-naphthyridine-3-carbonitrile | Articles data ｜lookchem

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305370-84-7

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SUBSTITUTED-3-CYANO-[1.7],[1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES
This invention provides compounds of formula (I) having structure (a) wherein A'' is a diavalent moiety selected from the group (a, b, c) which are useful as inhibitors of protein tyrosine kinase.
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Page 47

(2010/02/06)

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles
The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.
Wissner, Allan,Hamann, Philip R.,Nilakantan, Ramaswamy,Greenberger, Lee M.,Ye, Fei,Rapuano, Timothy A.,Loganzo, Frank
p. 1411 - 1416
(2007/10/03)

SUBSTITUTED 3-CYANO-[1.7], [1.5] AND [1.8] NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES
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Page column 56

(2010/02/05)

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Chemical Properties

Boiling Point: 440.6±40.0 °C(Predicted)
Density: 1 +-.0.1 g/cm3(Predicted)
PKA: -1.04±0.30(Predicted)
PSA: 95.39000
LogP: 2.58628

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