A new strategy for the synthesis of furan-3,4-dicarboxylic acid
A facile route to furan-3,4-dicarboxylic acid is described. Dimethylmaleic anhydride (1) on NBS-bromination followed by aqueous KOH treatment gave bis(hydroxymethyl)maleic anhydride (3), which on intramolecular Mitsunobu ring closure followed by esterification and DDQ-oxidation furnished the desired esters of furan-3,4-dicarboxylic acid 7a/b.
Deshpande, Anil M.,Natu, Arvind A.,Argade, Narshinha P.
p. 1010 - 1012
(2007/10/03)
A New and Versatile Synthesis of Furans
The thermal reaction of oxazoles 1 and acetylenic dienophiles 2 provides a synthetic approach to a great variety of furans (Table 1).Scope and mechanism of this reaction are discussed.Biologically active substances of type 7 are described as examples for practical application.
Koenig, Horst,Graf, Fritz,Weberndoerfer, Volkmar
p. 668 - 682
(2007/10/02)
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