- Fluorescent probe and fluorescence detecting method
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A fluorescent probe having a base sequence complementary to a specific sequence in a target nucleic acid, wherein the fluorescent probe has one end labeled with a nano particle fluorescent material, and the other end labeled with a fluorescent dye capable of fluorescence resonance energy transfer from the nano particle fluorescent material.
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- Method for detecting cancer using metal-oxide or metal-sulfide nanoparticle fluorescent material
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It is an object of the present invention to provide a nanoparticle fluorescent material for detecting cancer with which cancer can be detected with high sensitivity, using highly safe and broad light emission on a simple device. The present invention provides a nanoparticle fluorescent material which comprises a metal-oxide or metal-sulfide nanoparticle fluorescent material whose surface is modified by a surface modifying agent and whose half bandwidth of light emission is between 50 and 200 nm, wherein an antibody that recognizes cancer antigen is bound to the surface modifying agent.
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- Cleavage of cyclic organosilanes in the preparation of aminofunctional organoalkoxysilanes
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An aminofunctional organoalkoxysilane of formula I R2N—(CH2)y—Si(OR1)3?nR2n ??(I), wherein the R groups bonded to nitrogen are identical or different and each individual R group is hydrogen, an alkyl radical having from 1 to 4 carbon atoms, an aryl radical or an arylalkyl radical, R1 is an alkyl radical having from 1 to 8 carbon atoms or an aryl radical, R2 is an alkyl radical having from 1 to 8 carbon atoms or an aryl radical, y is 2, 3 or 4 and n is 0, 1 or 2, is prepared by a process comprising: reacting a chlorofunctional organoalkoxysilane of formula II Cl—(CH2)y—Si(OR1)3?nR2n ??(II), wherein R1, R2, y and n are as defined above, with ammonia or an organic amine of formula III HNR2 ??(III), wherein the two R groups are identical or different and each is defined as described above; separating organic amine hydrochloride or ammonium chloride by-product which is formed in the reaction; distilling the resulting crude product, thereby preparing an aminofunctional organoalkoxysilane or the product fraction of an aminofunctional organoalkoxysilane; and treating the aminofunctional organoalkoxysilane or the product fraction of an aminofunctional organoalkoxysilane with an alcohol.
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- Synthesis of 2-γ-N-(aminoethyl)aminopropyl-2-methyl-6-alkyl(aryl,H)-1,3-dioxa-6- aza-2-silacyclooctanes
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Some new 2-γ-N-(aminoethyl)aminopropyl-2-methyl-1,3-dioxa-6-aza-2- silacyclooctane and 2-γ-N-(aminoethyl)aminopropyl-2-methyl-6-alkyl(aryl)-1,3-dioxa-6-aza- 2-silacyclooctanes have been synthesized from γ-chloropropyldimethoxymethyl silane by ethylenediamine substitution and diethanolamine or N-alkyl(aryl)diethanolamines substitution. The resulting silocanes have been characterized by elemental analyses, IR, and 1H NMR.
- Yang,Lin,Li
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p. 2817 - 2822
(2007/10/03)
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