- A convenient "one-pot" reaction for selective monoalkylation of N,N′-disubstituted ethylenediamines
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A study on the scope of the method to obtain N,N,N′-trisubstituted ethylenediamines III by monoalkylation of N,N′-disubstituted ethylenediamines I through a "one-pot" reaction is presented. It involves condensation of compounds I with aldehydes followed by reduction of the formed imidazolidines II without previous isolation.
- Salerno, Alejandra,Figueroa, Maria Amalia,Perillo, Isabel A.
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p. 3193 - 3204
(2007/10/03)
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- H NMR spectroscopy and conformational analysis of N-benzylimidazolidines
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H NMR spectra of a series of 1-benzyl- and 1,3-dibenzylimidazolidines are analyzed and correlated with their conformational features. The spectra are assigned on the basis of chemical shifts and proton coupling constant values, and confirmed by NOESY spectra. C2-Unsubstituted imidazolidines (1,9) show a fast inversion of the nitrogen atoms. By contrast, 1,2,3-trisubstituted imidazolidines display a preferential conformation with a transoid orientation of the N1, N3, and C2 substituents.
- Perillo, Isabel A.,De los Santos, Carlos,Salerno, Alejandra
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