Construction of the tetrahydroquinoline spiro skeleton: Via cascade [1,5]-hydride transfer-involved C(sp3)-H functionalization "on water"
The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-base
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
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Page/Page column 266; 267
(2015/07/07)
Protecting-group-free amination of halogenated nitrobenzaldehyde with palladium catalyst
"One-step" method for the synthesis of secondary aliphatic amine substituted nitrobenzaldehyde was developed. In the presence of Pd catalyst, halogenated nitrobenzaldehyde could be smoothly coupled with secondary aliphatic amine to give the target product
Cao, Jing,Feng, Jun Xiang,Wu, Yong Xiang,Tuo, Ya Ya
experimental part
p. 935 - 938
(2011/11/13)
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