- Preparation of organocobalt(iii) complexesviaO2activation
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The coupling of selective C-H activation with O2activation is an important goal for organic synthesis. New experimental and computational results, along with the results from experimental work accumulated over many decades, now unequivocally link O2activation with C-H activation by the classic Co(salen) complexes. A common holistic mechanistic framework can rationalise the formation of ostensibly diverse peroxo, superoxo, organo and alkoxide complexes of CoIII(salen). DFT calculations show that cobalt(iii)superoxo, dicobalt(iii)peroxo and cobalt(iii)hydroperoxo complexes are all viable intermediates as participants in hydrogen atom transfer reactions, whereas a Co(iv)oxo intermediate is unlikely. The reaction conditions will determine the pathway followed and all pathways are initiated through the initial formation of a superoxo complex, CoIII(salen)(O2?)(MeOH) (EPR:g= 2.025,A= 19 G). Organo and alkoxide ligands are derived from solvent media and the trends in reactivity reveal that combination of the pKaand BDE of the C-H of the respective solvent substrates are important. These data explain why landmark, structurally characterized, μ2-?1,?2-peroxide and ?1-superoxide Co(salen)-O2adducts were predominantly isolated from solvents with high C-H pKavalues (DMSO, DMF, DMA).
- Kongsted, Jacob,M?ller, Mads Sondrup,McKenzie, Christine J.
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supporting information
p. 4819 - 4829
(2021/04/22)
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- A silver-catalyzed radical ring-opening reaction of cyclopropanols with sulfonyl oxime ethers
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A silver-catalyzed ring-opening reaction of cyclopropanols with sulfonyl oxime ethers has been developed. The protocol was conducted under mild reaction conditions to provide a series of ?-keto oxime ethers with moderate to good yields. The reaction proceeded in a stereoselective manner for CF3-containing oxime ethers to provide a single stereoisomer, while an inseparableEandZmixture was obtained for CN-containing oxime ethers. Mechanistic studies indicate that the reaction proceededviaa radical mechanism.
- Wang, Xin,Zeng, Xiaobao,Zhang, Yanan,Zhao, Yu,Zhu, Li
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supporting information
p. 3734 - 3739
(2020/06/03)
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- Direct Acyl Radical Addition to 2 H-Indazoles Using Ag-Catalyzed Decarboxylative Cross-Coupling of α-Keto Acids
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A direct acyl radical addition to 2H-indazoles has been achieved for the first time, where the less-aromatic quinonoid 2H-indazoles readily accepted radical species to the C-3 position. Motivated by the lack of direct acylation strategy for 2H-indazoles, the current method utilizes the radical acceptability of 2H-indazoles, discovering an ambient temperature reaction to provide facile access to a diverse array of 3-acyl-2H-indazoles with three points of structural diversification in 25%-83% yields.
- Bogonda, Ganganna,Kim, Hun Young,Oh, Kyungsoo
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supporting information
p. 2711 - 2715
(2018/05/22)
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- A radical anti-Markovnikov addition of alkyl nitriles to simple alkenes via selective sp3 C-H bond functionalization
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An efficient hydrocyanoalkylation of unactivated alkenes with alkyl nitriles was developed. Through this free-radical-initiated selective activation of the α-C(sp3)-H bond of acetonitriles, an anti-Markovnikov addition of an α-cyano C-centered radical to olefins has been achieved, which allows a facile and convenient access to functionalized nitriles in large scales.
- Li, Zejiang,Xiao, Yingxia,Liu, Zhong-Quan
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supporting information
p. 9969 - 9971
(2015/06/22)
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