Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
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Page/Page column 117-118
(2010/01/31)
Switchable Catalysis: Modular Synthesis of Functionalized Pyrimidinones via Selective Sulfide and Halide Cross-Coupling Chemistry
(Equation presented) A general demonstration of orthogonal selectivity of the Liebeskind-Srogl cross-coupling protocol compared to the Suzuki-Miyaura and Stille variants is reported.
Kusturin, Carrie,Liebeskind, Lanny S.,Rahman, Hayat,Sample, Kirby,Schweitzer, Barbara,Srogl, Jiri,Neumann, William L.
p. 4349 - 4352
(2007/10/03)
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