4-amino-fluorobenzamides and their use as cytotoxic prodrugs
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) STR1 wherein R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2, and M is a nitrogen mustard group of the formula STR2 wherein Y and L, which may be the same or different in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.
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(2008/06/13)
Improvements relating to the production of prodrugs
The invention provides compounds of the formula XX: M-Ar-CONH-R, where Ar represents an aromatic ring system, R-NH is the residue of an α-amino acid R-NH2 or oligopeptide R-NH2 and contains at least one carboxylic acid group in the f
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(2008/06/13)
Novel Prodrugs Which Are Activated to Cytotoxic Alkylating Agents by Carboxypeptidase G2
The synthesis of three novel prodrugs, 4-amino>benzoyl-L-glutamic acid (7), 4-amino>benzoyl-L-glutamic acid (8), and 4-benzoyl-L-glutamic acid (9), for use as anticancer ag
Springer, Caroline J.,Antoniw, Pari,Bagshawe, Kenneth D.,Searle, Frances,Bisset, Graham M. F.,Jarman, Michael
p. 677 - 681
(2007/10/02)
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