4 - arylmethyl curcumin analogs as Hsp90 inhibitors
The invention discloses application of a 4-arylmethyl curcumin analogues serving as an Hsp90 inhibitor. The 4-arylmethyl curcumin analog in serving as Hsp90 inhibitor has a structural formula as shown in the specification, wherein Ar is aromatic ring or a
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(2017/08/25)
Synthesis and evaluation of 4-arylmethyl curcumin analgues as potent Hsp90 inhibitors
Hsp90 is a potential target for the treatment of cancer. Curcumin is a natural product used to prevent and treat cancer. 4-(4-Hydroxy-3-methoxybenzyl) curcumin (C086), a 4-arylmethyl curcumin analogue, showed lead-like properties. Western blot analyses an