- Electron-withdrawing, bipheny 1-2,2 -diol-based compounds for asymmetric catalysis
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Facile synthetic routes to a chiral chloro-substituted biphenyl-2,2′- diyl hydrogen phosphate and a chiral O,O-biphenyl-2,2′-diyl phosphoramidothioate are described. The performance of these compounds as catalysts for the hydrophosphorylation of imines and the Friedel-Crafts alkylation of indole was investigated. In the latter reaction, the chlorosubstituted phosphoric acid derivative was found to rival the best Bronsted acid catalysts reported to date.
- Gutierrez, Elisa G.,Moorhead, Eric J.,Smith, Eva H.,Lin, Vivian,Ackerman, Laura K. G.,Knezevic, Claire E.,Sun, Victoria,Grant, Sharday,Wenzel, Anna G.
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experimental part
p. 3027 - 3031
(2010/08/07)
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- 2- ( 2 -HYDROXYPHENYL) -QUINAZOLIN-4-ONES USEFUL FOR TREATING OBESITY AND DIABETES
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The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
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Page/Page column 14
(2010/10/19)
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- 2- ( 2 -HYDROXYPHENYL) -QUINAZOLIN-4-ONES USEFUL FOR TREATING OBESITY AND DIABETES
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The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
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Page/Page column 36; 38
(2008/12/05)
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- NOVEL 2-(2-HYDROXYPHENYL) BENZOTHIADIAZINES USEFUL FOR TREATING OBESITY AND DIABETES
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The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
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Page/Page column 36; 38-39
(2008/12/05)
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- NOVEL 2-(2-HYDROXYPHENYL)BENZIMIDAZOLES USEFUL FOR TREATING OBESITY AND DIABETES
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The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful, inter alia, in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.
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Page/Page column 37; 40-41
(2008/12/05)
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