- Photoinduced properties of methyl ester of 2,6-dimethyl-1-amino-4-benzoic acid: Evidence of charge transfer emission from a weak primary amino donor
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Photophysical properties of methyl ester of 2,6-dimethyl-1-amino-4-benzoic acid (M26DMB) have been investigated using steady state absorption and emission spectroscopy and time-resolved emission spectroscopy. Interestingly, not only in polar solvents, the molecule M26DMB having a weak primary amino donor group shows broad red-shifted emission band even in non-polar environment which in all probability arises from closely spaced local and charge transfer (CT) states. Clear dual fluorescence in polar protic solvents comprises of less intense local emission band and strong red-shifted CT band. The position of the red-shifted emission band is dependent on both the polarity and the hydrogen-bonding ability of the solvent.
- Ghosh, Shalini,Chakraborty, Amrita,Kar, Samiran,Guchhait, Nikhil
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- Nainai non-west tanzania intermediate 2, 6 - dimethyl aniline synthesis method
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The invention discloses a nainai non-west tanzania intermediate 2 - pyrrolidone synthetic method, the 4 - amino - 3 - methyl benzoate with halogenated methane under the effects of catalyst obtained by reaction of 2, 6 - dimethyl aniline, the 4 - amino - 3 - methyl benzoate, protective agent and solvent A reaction mixture obtained from I; halogenated methane, catalyst and solvent B mixing, then mixing the mixture I II into the reaction mixture; adding an aqueous solution of hydrochloric acid in the reaction mixture is mixed with the mixture II III; III will be alkali water dripped into the mixture, the reaction mixture obtained from IV; the mixture is poured into the IV 3 - 4 times of the volume of water, added with a solvent extracting C, layered, organic layer after the water washing, after drying agent, concentrated evaporate the solvent to obtain the product. The method of low cost, high yield, blowdown less.
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Paragraph 0032; 0038; 0050; 0056
(2019/06/13)
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- Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists
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A novel series of EP4 antagonists, based on a quinoline scaffold, has been discovered. Medicinal chemistry efforts to optimize the potency of the initial hit are described. A highly potent compound in a clinically relevant human whole blood assay was iden
- Blanco, Maria-Jesus,Vetman, Tatiana,Chandrasekhar, Srinivasan,Fisher, Matthew J.,Harvey, Anita,Mudra, Daniel,Wang, Xu-Shan,Yu, Xiao-Peng,Schiffler, Matthew A.,Warshawsky, Alan M.
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p. 105 - 109
(2015/12/18)
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- DIMETHYLBENZOIC ACID COMPOUNDS
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The present invention provides a compound of the Formula I: wherein A is: and W, Y, X, R1, R2, R3, and R4 are as defined herein, or a pharmaceutically acceptable salt thereof, for use as an inhibitor of the EP4 receptor.
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- DIMETHYL-BENZOIC ACID COMPOUNDS
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The present invention provides a compound of the Formula II: wherein A is: * R 1 is CH3, CF 3, or F; * R 2 is H, CH3, or F; * R 3 is CH3, OCH 3, OH, F; R 4 is OH or CH 20H; and *
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- Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
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The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single
- Corbett,Dirico,Song,Boscoe,Doran,Boyer,Qiu,Ammirati,VanVolkenburg,McPherson,Parker,Cox
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p. 6707 - 6713
(2008/09/17)
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- Novel selective hindlimb vasodilators: Synthesis and biological activity of 1-acyl-4-aminopiperidine derivatives
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A series of 6-(4-amino-1-piperidinyl)carbonyl-2(1H)-quinolinones, and their open form derivatives, were synthesized and evaluated for their ability to stimulate femoral artery blood flow (FBF) in the canine hindlimb. All members of this series stimulated
- Teramoto, Shuji,Tanaka, Michinori,Shimizu, Hiroshi,Fujioka, Takafumi,Tabusa, Fujio,Imaizumi, Takashi,Yoshida, Kenji,Fujiki, Hiroyuki,Mori, Toyoki,Sumida, Takumi,Tominaga, Michiaki
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p. 3033 - 3044
(2007/10/03)
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- N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
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Thienyl-, furyl- and pyrrolyl-sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
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Page column 125
(2010/01/30)
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- LOCAL ANESTHETIC COMPOUNDS AND USES
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Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na + channel to modulate the biological processes/functions thereof.
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- Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
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Biphenylsulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, bicyclic or tricyclic carbon or heterocyclic ring biphenylsulfonamides and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.
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- Anovulatory method and chicken feed compositions
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2-(Substituted phenylimino)imidazolidines delay the onset of egg production in young pullets and inerrupt egg production in mature hens and are useful in producing an artificial molt.
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