- Hexabromotricyclobutabenzene and hexabromohexaradialene: Their nickel-mediated one-pot syntheses and crystal structures
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The reaction of hexakis(dibromomethyl)benzene with [(Bu3P)2Ni(COD)] (COD - 1,5-cyclooctadiene) in DMF at 65 70 C yielded a mixture of the title compounds. The mixture was separated by column chromatography to yield hexabromotricyclobutabenzene (3a) and hexabromohexaradialene (4) in 24 and 16% yields, respectively. 1H and 13C NMR spectroscopy suggest that 3 is obtained as the syn-all-trans isomer 3a, and the symmetric anti-all-trans isomer 3b is not obtained at all. The X-ray structures of 3a and 4 are reported. The hexaradialene 4 has a chair conformation, and deviates from planarity by 43.6. Heat or radical impurities cause the clean transformation of 3a to 4.
- Stanger, Amnon,Ashkenazi, Nissan,Boese, Roland,Blaeser, Dieter,Stellberg, Peter
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- SUPEPANes SUPEFANE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF
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The invention discloses a superhanes super-phane compound and a preparation method and application thereof, the superhanes super-phane compound is independently selected from one or more of an imine type superhanes compound, a secondary amine type superhanes compound and a tertiary amine type superhanes compound, and X is selected from a straight-chain carbon chain, an alicyclic group, an aromatic ring group, an alicyclic ring group, an aromatic ring group, a metal complex and a supramolecular macroring. According to the superhanes super-phane compound with the structure and the preparation method and application thereof, the compound has the advantages of being high in symmetry, adjustable in recognition cavity size, multiple in recognition site in a cavity and the like, has liquid fluorescence and solid fluorescence at the same time, and can be applied to ion recognition and separation, neutral molecule capture and cell imaging.
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- N-type star-shaped polycyclic conjugated aromatic hydrocarbon and synthesis method thereof
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The invention discloses N-type star-shaped polycyclic conjugated aromatic hydrocarbon and a synthesis method thereof. The structural general formula of the N-type star-shaped polycyclic conjugated aromatic hydrocarbon is shown in the specification, wherein R in the general formula is C6-C40 alkyl, C6-C40 alkyl ester, C6-C40 alkylamide or a C6-C40 aromatic substituent. The N-type star-shaped polycyclic conjugated aromatic hydrocarbon is a novel N-type star-shaped polycyclic conjugated aromatic hydrocarbon. Meanwhile, the synthetic method is short in synthetic route, simple and convenient to operate, mild in reaction condition and easy to control, and does not need special equipment.
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Paragraph 0040; 0045-0046
(2020/01/25)
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- Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer
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The pharmacological importance, particularly the anti-cancer and chemopreventive potentials, of organochalcogen compounds has attracted wide research attention recently. Herein we describe the synthesis of a series of organochalcogenocyanates that have one or more selenocyanate or thiocyanate units in a single molecule. The anti-proliferative activity of these organochalcogenocyanates in different breast cancer cells shows that selenocyanates exhibit much higher anti-proliferative activities than thiocyanates in general. Our study reveals that the activity of benzyl selenocyanate (1, BSC) could be significantly enhanced by 4-nitro substitution (12), which was more selective towards triple-negative breast cancer cells (MDA-MB-231) over other ER+ breast cancer cells (MCF-7 and T-47D). Furthermore, to the best of our knowledge, this is the first report on the synthesis of compounds having more than two selenocyanate units with promising anti-proliferative activities. Our studies further indicate that the apoptotic activities of selenocyanates are associated with modulation of cellular morphology and cell cycle arrest at S-phase. Selenocyanates also inhibited cellular migration and exhibited weak antioxidant activities. An effective binding interaction of compound 12 with serum albumin indicates its feasible transport in the bloodstream for its enhanced anti-cancer properties. Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies. The results of this study would be helpful in designing suitable chemotherapeutic and chemopreventive drugs in the future.
- Banerjee, Kaustav,Padmavathi, Ganesan,Bhattacherjee, Debojit,Saha, Suchismita,Kunnumakkara, Ajaikumar B.,Bhabak, Krishna P.
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supporting information
p. 8769 - 8782
(2018/11/30)
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- Mercaptothiazolinyl functionalized hexapodal and tripodal receptors on benzene platform: Formation of silver ion assisted hexanuclear metallocage vs metalO-rganic polymer
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Mercaptothiazolinyl functionalized hexapodal (L1) and tripodal (L2) receptors on the benzene platform have been synthesized easily in good yields and structurally characterized by a single-crystal X-ray crystallographic study. In the solid state, L1 shows an orientation of six arms in 1,3,5 vs 2,4,6 facial steric gearing fashion, whereas L 2 adopted C2v symmetry where two of its thiazolinyl arms are oriented in one direction and the third arm in the another direction. Two silver complexes of L1, 1 ([2(L1)·6(AgClO 4)·2(CHCl3)·HClO4]) and 2 ([2(L1)·6(AgClO4)]), that are suitable for single-crystal X-ray studies are isolated upon the slow diffusion of a dimethylformamide solution of AgClO4 to the solution of L1 in chloroform and dichloromethane, respectively. Similarly, upon the slow diffusion of an acetonitrile solution of AgClO4 to the chloroform solution of L2, colorless crystals of the silver complex of L 2, 3, are successfully isolated. The structural analyses of 1 and 2 show the formation of a silver ion assisted hexanuclear metallocage Ag 6(L1)2 via dimeric assembly of L1 with multiple clefts and pockets toward guests binding. In 1, two chloroform molecules sit in top and bottom pockets, whereas six perchlorate counteranions are bound in six clefts between the silver ion pillared side arms of the metallocage. Though complex 2 shows the formation of a metallocage like 1, the single crystal structural analysis depicts perchlorate counteranions bonded to the silver atoms of the metallocage. On the contrary, the silver complex of tripodal receptor L2, 3, shows the formation of a metallo-organic polymeric network of L2 and Ag+. To the best of our knowledge, this work represents the first report on the formation of an M 6L2 type metallosupramolecular cage topology with multiple clefts for guest binding by a semirigid hexapodal receptor.
- Ahamed, B. Nisar,Arunachalam,Ghosh, Pradyut
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scheme or table
p. 4772 - 4780
(2011/07/30)
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- Composition comprising polymers having a star structure, the polymers, and their use
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A composition, comprising, in a physiologically acceptable medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of caring for the skin, in particular of the face, and more especially for treating, that is to say decreasing, erasing and/or smoothing out, wrinkles and/or fine lines of the skin.
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- Composition comprising polymers having a star structure, the polymers, and their use
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A composition, in particular a cosmetic composition, comprising, in an appropriate medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of make-up and are capable of being applied to the skin, semi-mucous membranes and/or mucous membranes. In particular, these compositions can be provided in the form of a transfer-free make-up composition.
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- Composition comprising polymers having a star structure, the polymers, and their use
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A composition, comprising, in a physiologically acceptable medium, at least one polymer with a highly specific ordered structure is disclosed. These compositions find a specific application in the field of caring for or making up keratinous fibres, in particular as a mascara composition for the eyelashes or for the hair.
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- A facile synthesis of hexakis(bromomethyl)benzene from mesitylene
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Exhaustive bromomethylation of 1,3,5-trimethylbenzene (mesitylene) followed by bromination affords the title compound in high purity and excellent yields.
- Zavada,Pankova,Holy,Tichy
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p. 1132 - 1132
(2007/10/02)
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- Synthesis of 1,2,3,4,5,6-hexakis (?-methylene) benzene compounds of iron and cobalt carbonyls and their facile conversion into ?-compounds
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The complexes 1,2,3,4,5,6-hexakis (?-methylene) benzenedodecacarbonyltriiron (1) and 1,2,3,4,5,6-hexakis (?-methylene tetracarbonylcobalt) benzene (3) have been synthesized by the reactions of 1,2,3,4,5,6-hexakis (bromomethyl)benzene with disodium tetracarbonylferrate and sodium tetracarbonylcobaltate, respectively.Complex 1 undergoes facile conversion into complex 2 where a ? to ?-conversion occurs with three Fe(CO)3 moieties separately coordinated to three butadiene fragments.Attempts to convert complex (3) into ?-form are, however, unsuccessful.
- Ullah, S. S.,Azam, K. A.,Kabir, S. E.,Rahman, A. K. F.,Begum, R.
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- Structure and Reactivity of Isoannellated Heterocyclic Systems with 4n?- and (4n+2)?-Electrons, XIV. Tri- and Tetracyclic Hetarenes with Localized or Delocalized Pyrrole Units
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2,7-Di-tert-butyl-2,7-dihydro-benzodipyrrole (2b) and 2,5,8-Tri-tert-butyl-5,8-dihydro-2H-benzotripyrrole (3b) have been prepared by acetolysis of the corresponding tri- and tetracyclic N-oxides, isolated in crystallinic form and characterized by spectroscopic data.The scope of the N-oxide route is documented and the existence of benzo-annellated pyrroles is proofed.The stabilizing effect of the tert-butyl group is presumably supported by the vicinal annellated heterocycles. - Keywords: Benzo-annellated Di- and Tripyrroles, Synthesis, Isolation, Spectroscopic Properties, Cycloaddition reactions
- Kreher, Richard P.,Hildebrand, Thomas
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p. 125 - 131
(2007/10/02)
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- DESIGN, SYNTHESIS AND CHARACTERIZATION OF THE MOLECULAR COMPONENTS OF ORGANIC CONDUCTORS.
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Following an examination of the design constraints for the formulation of good organic conductors and a brief review of the synthesis of heterocyclic selenium pi -donors such as TMTSF and the zero pressure organic superconductor (TMTSF)//2ClO//4, the preparation and characterization of five new pi -donors is outlined. These new pi -donors are dithiophenotetrathiafulvalene, (DTTTF), dithiophenotetraselenafulvalene (DTTSF), dibenzotetraselenafulvalene (DBTSF), dibenzotetratellurafulvalene (DBTTeF), and benzotrisselenophene (BTS).
- Cowan,Kini,Chiang Long-Yong,Lerstrup,Talham,Poehler,Bloch
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