- Benzylic oxygenation of alkylarenes with molecular oxygen in the presence of activated carbon
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A variety of alkylarenes such as fluorenes, xanthenes, and anthrone were effectively oxygenated to the corresponding carbonyl compounds with molecular oxygen as oxidant in the presence of activated carbon.
- Kawabata, Hirotoshi,Hayashi, Masahiko
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- Oxidative transformation of 2-acetylaminofluorene by a chemical model for cytochrome P450: A water-insoluble porphyrin and tert-butyl hydroperoxide
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Oxidation of 2-acetylaminofluorene (AAF), a carcinogen, by a chemical model for cytochrome P450 was investigated to identify an active mutagen and elucidate the oxidation pathway. The oxidation system consisted of a water-insoluble tetrakis(pentafluorophenyl)porphyrinatoiron(III) chloride and tert-butyl hydroperoxide. The mutagen derived from AAF by the chemical model was 2-nitro-9-fluorenone (NO2F{double bond, long}O), which was mutagenic in Salmonella typhimurium TA1538. AAF was oxidized initially at position 9 of the fluorene carbon by the chemical model forming 2-acetylamino-9-fluorenol (AAF-OH), and then oxidized further to 2-acetylamino-9-fluorenone (AAF{double bond, long}O) as a major product. Initial oxidation of the nitrogen formed 2-nitrofluorene (NO2F), and further oxidation yielded 2-nitro-9-fluorenol (NO2F-OH) as a minor product. These products, AAF-OH, AAF{double bond, long}O, NO2F, and NO2F-OH, and their presumable common intermediate, N-hydroxy-2-acetylaminofluorene, were oxidized by the chemical model, and the formation of NO2F{double bond, long}O was determined. These results showed that NO2F{double bond, long}O was the mutagen derived from AAF in the presence of the chemical model and was formed via oxidation of N-OH-AAF, NO2F, and NO2F-OH. These results may lead to a new metabolic pathway of AAF.
- Inami, Keiko,Mochizuki, Masataka
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- COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING DERIVATIVES OF FLUORENE
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This invention is directed to, inter alia, compounds, methods, systems, and compositions for the maintenance, enhancement, and expansion of hematopoietic stem cells derived from one or more sources of CD34+ cells. Sources of CD34+ cells include bone marrow, cord blood, mobilized peripheral blood, and non-mobilized peripheral blood. Also provided herein are compounds of Formula I which are useful in maintaining, enhancing, and expanding of hematopoietic stem cells.
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Paragraph 0402
(2019/05/15)
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- Oxidation of secondary benzylic alcohols to ketones and benzylic oxygenation of alkylarenes with hydrogen peroxide in the presence of activated carbon
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A variety of benzylic alcohols were oxidized to the corresponding carbonyl compounds selectively with 30% hydrogen peroxide (H in the presence of activated carbon. Alkylarenes such as fluorenes, xanthenes, and anthrone were also effectively oxygenated to the corresponding carbonyl compounds with 30% Has oxidant in the presence of activated carbon. Georg Thieme Verlag Stuttgart · New York.
- Nishida, Shunsuke,Hayashi, Masahiko
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experimental part
p. 1683 - 1685
(2012/08/13)
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- A novel catalytic role of molecular iodine in the oxidation of benzylic alcohols: Microwave-assisted reaction
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Molecular iodine was used to catalyse the oxidation of several benzylic alcohols to the corresponding ketones under the microwave-irradiated method, and the role of iodine was explored.
- Mukhopadhyay,Becker,Banik
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