- PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS
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The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).
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- Efficient preparation of carbamates by Rh-catalysed oxidative carbonylation: unveiling the role of the oxidant
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The synthesis of a wide variety of carbamates from amines, alcohols and carbon monoxide has been achieved by means of a Rh-catalysed oxidative carbonylation reaction that uses Oxone as a stoichiometric oxidant. In-depth studies on the reaction mechanism shed light on the intimate role of Oxone in the catalytic cycle.
- Iturmendi, Amaia,Iglesias, Manuel,Munárriz, Julen,Polo, Victor,Pérez-Torrente, Jesús J.,Oro, Luis A.
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supporting information
p. 404 - 407
(2017/01/03)
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- Chloroformate free, scalable approach for the synthesis of organic carbamates and their alkylation
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A convenient method for the synthesis of organic carbamates of 2-aminopyridine without using hazardous chloroformate reagent is developed. This alternate approach for the synthesis of organic carbamates and their alkylation to 2-alkylaminopyridines is more practical and economical to be used on large scale. The amazing behavior of 2- aminopyridine helps in forming organic carbamates unlike 3-aminopyridine and 4-aminopyridine.
- Shewalkar, Mukesh P.,Rao, Ramakrishna R.,Reddy, Veerbhadra,Darandale, Sunil N.,Shinde, Devanand B.
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