- T3P-Mediated N-N Cyclization for the Synthesis of 1,2,4-Triazolo[1,5- a]pyridines
-
Propylphosphonic anhydride has been shown to be an effective reagent for the synthesis of substituted [1,2,4]triazolo[1,5-a]pyridines from the corresponding N′-hydroxy-N-formimidamides. The reactions worked under mild conditions and exhibited wide functional group tolerance, delivering the triazolopyridines in good to excellent yields and purities.
- Ayothiraman, Rajaram,Bandaru, Durgarao,Paranthaman, Ranjitha,Fenster, Micha?l,Eastgate, Martin D.,Vaidyanathan, Rajappa
-
p. 2510 - 2515
(2019/11/11)
-
- Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]- and [1,5-a]pyridine cores
-
Six sets of functionalized building blocks based on 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine as well as 5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine cores have been prepared. These compounds are non-flat, bicyclic heterocycles that are likely to find utility as privileged motifs for lead-like compound design. One set of building blocks, (5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ylmethyl)amines, proved useful as a scaffold for developing compounds that stimulate glucagon-like peptide-1 (GLP-1) secretion and are novel anti-diabetes drug leads.
- Mishchuk, Alexander,Shtil, Natalia,Poberezhnyk, Mykola,Nazarenko, Konstiantyn,Savchenko, Timur,Tolmachev, Andrey,Krasavin, Mikhail
-
p. 1056 - 1059
(2016/02/16)
-