The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.
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Page/Page column 37
(2008/12/07)
Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists
A series of constrained piperidine analogues were synthesized as novel muscarinic M3 receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M3 receptor but also have high selectivity over the M2 receptor.
Kumar, Naresh,Kaur, Kirandeep,Aeron, Shelly,Dharmarajan, Sankaranarayanan,Silamkoti, Arun D.V.,Mehta, Anita,Gupta, Suman,Chugh, Anita,Gupta, Jang B.,Salman, Mohammad,Palle, Venkata P.,Cliffe, Ian A.
p. 5256 - 5260
(2008/02/11)
Ethyl Mandelate as a Convenient New Benzoyl Anion Equivalent
Ethyl mandelate acts as a convenient benzoyl anion equivalent for the formation of alkyl aryl ketones by deprotonation-alkylation followed by flash vacuum pyrolysis.
Aitken, R. Alan,Thomas, Andrew W.
p. 293 - 294
(2007/10/03)
Studies on spasmolytics. VI. The effect of structural "changes" in nitrogen-free spasmolytic esters: hexahydrobenzilic acid esters.
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FUNCKE,REKKER,ERNSTING,TERSTEEGE,NAUTA
p. 767 - 769
(2007/10/05)
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