HALOSILANES IN THE SYNTHESIS OF N-(HALOMETHYL) DERIVATIVES OF LACTAMS, N-METHYLCARBOXAMIDES, AND IMIDES
Methods are proposed for the synthesis of N-(halomethyl) derivatives of lactams, N-methylcarboxamides, and imides with the use of the paraform-chlorotrimethylsilane system and the replacement of the trimethylsiloxy group by halogen and of halogen by halogen by the action of halotrimethylsilanes or acetyl bromide.The reactions of N-(chloromethyl)lactams with carboxylic anhydrides lead to N-(acyloxymethyl)lactams.