Chiral (o-Hydroxyaryl)oxazaphospholidine oxides: A new class of bifunctional catalysts in the enantioselective borane reduction of ketones
The synthesis of a new class of bifunctional organophosphorus catalysts for the asymmetric borane reduction of prochiral ketones has been investigated. Keys to the architecture of effective catalysts are an oxazaphospholidine structural unit and a hydroxyaryl moiety. These (o-hydroxyaryl)oxazaphospholidine oxides have been successfully applied to the catalytic (2 mol-%) asymmetric borane reduction of numerous prochiral ketones with enantiomeric excesses up to 84% ee.
Brunel, Jean Michel,Legrand, Olivier,Buono, Gerard
p. 3313 - 3321
(2007/10/03)
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