- DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF
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The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.
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Paragraph 000547
(2020/07/14)
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- Four- and Five-Coordinate Titanium(IV) Complexes Supported by the dpp-bian Ligand in ROP of L-Lactide
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A titanium(IV) alkoxido complex, (dpp-bian)Ti(OBn)2 (2), as well as alkoxido chlorido complexes (dpp-bian)TiCl(OCH2CH2OMe) (3) and (dpp-bian)TiCl2OBn (4), were synthesized from the titanium(IV) dichloride precursor [(dpp-bian)TiCl2]2 (1) by exchange with corresponding sodium salts (comps. 2 and 3) or by the alcoholysis with BnOH (comp. 4). The compounds 2–4 were fully characterized by elemental analysis, NMR or EPR, and IR spectroscopy. Molecular structures of the metal complexes in the solid state have been determined by single-crystal XRD analysis. Compounds 2–4 were tested as catalysts in the ROP of L-lactide in a toluene medium. Whereas complexes 2 and 3 produce cyclic PLAs with broad dispersities and unpredictable molecular weights, complex 4 acts as an efficient ROP catalyst which polymerizes the monomer in a highly controllable manner. It produces BnO-capped PLAs with narrow molecular weight distributions as well as linear dependence of Mns on monomer conversion.
- Morozov, Alexander G.,Martemyanova, Tatyana V.,Dodonov, Vladimir A.,Kazarina, Olga V.,Fedushkin, Igor L.
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p. 4198 - 4204
(2019/09/17)
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- TLR AGONISTS
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The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore.
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Page/Page column 24-25
(2008/06/13)
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- Fused pyridine derivatives
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The present provides a condensed pyridine compound (I) represented by the following formula: (wherein, R2represents ring A represents benzene ring, pyridine ring, thiophene ring or furan ring; and B represents its pharmaceutically acceptable salt or hydrates thereof, which is a clinically useful medicament having a serotonin antagonism, in particular, that for treating, ameliorating or preventing spastic paralysis or central muscle relaxants for ameliorating myotonia.
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- Water-soluble phosphazene polymers having pharmacological applications
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Novel poly(organophosphazene) polymers are used for the controlled release of pharmaceuticals, pesticides, herbicides, plant growth regulators and fertilizers. These polymers also act as foam control agents.
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- o-Aminophenol compounds
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o-Aminophenol derivatives are described represented by the formula (I) STR1 wherein R represents --NH2 or --NH--CO--R6 ; R1 and R2 which may be the same or different, each can represent an alkyl group or an aromatic group, or R1 and R2 together can form a ring; or R1, R2 and R3 together can form a ring ; R3 represents hydrogen, an alkyl group or an aromatic group; R4 can represent an alkyl group or an aromatic group; R5 can represent an alkyl group, an alkoxy group, an alkylthio group, an arylthio group, a halogen atom or an acylamino group; and n is 0, 1 or 2; R6 represents an alkyl group or an aromatic group; and R4 and R5 together can form a heterocyclic ring, R1 and R4 together can form a heterocyclic ring, or R1 and R5 together can form a ring; and R1, R2, R3, R4, and R5n have a total of 7 or more carbon atoms.
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- Preparation of alkyl cyanoacetates
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The alkyl cyanoacetates are prepared by reacting an alkyl chloracetate with an excess of an alkali metal cyanide, in an inert solvent and in the presence of at least one tertiary amine sequestering agent having the formula:
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- Process for solubilizing organic or mineral salts in organic solvents
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The invention provides a process for solubilizing an organic or mineral salt in an organic solvent, said process comprising contacting an organic or mineral salt of the formula A- M+, wherein A- represents a mineral or organic anion and M+ represents a cation selected from the group consisting of the cation NH4+ and its derivatives and the cations derived from the metals of the groups IA, IIA, IIIA, IVA, VA, VIA, VIIA, VIII, IB, IIB, IIIB, IVB and VB of the periodic table, with at least one sequestering agent which is soluble in said organic solvent, said sequestering agent having the formula: wherein n is an integer from 0 to 10 inclusive; R1, R2, R3 and R4, which can be the same or different, are each a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms; R5 is an alkyl radical having 1 to 12 carbon atoms, a cycloalkyl radical having 3 to 12 carbon atoms, a phenyl radical, a radical of the formula STR1 or a radical of the formula STR2 and m is an integer from 1 to 12 inclusive. The process makes it possible to utilize the A- M+ salt as a reactant in solvents in which such reaction has not heretofore been possible, or to extract the A31 M+ salt from a solution containing it.
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- 2-Alkoxyalkoxy-5-nitrobenzenesulfonic acid and salt thereof
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A 2-alkoxyalkoxy-5-nitrobenzenesulfonic acid or a salt thereof represented by the following general formula (I): STR1 wherein R1 represents an alkylene group having 2 or more carbon atoms; R2 represents an alkyl group; and M represents an inorganic or organic cation. The compound represented by the general formula (I) is useful as an intermediate for a dye releasing redox compound which is suitable for use in the color diffusion transfer process.
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- 2-Alkoxyalkoxy-5-aminobenzenesulfonic acid
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A 2-alkoxyalkoxy-5-aminobenzenesulfonic acid represented by the following general formula (I): STR1 wherein R1 represents an alkylene group having 2 or more carbon atoms; and R2 represents an alkyl group. The compound can be used as an intermediate in the production of a dye releasing redox compound.
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