- SUBSTITUTED PYRIMIDINONE-PHENYL-PYRIMIDINYL COMPOUNDS
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The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
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Paragraph 0330
(2013/06/26)
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- Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-Dihydroxy-2-propoxy)methyl]- derivatives of 5-substituted-2,4-Difluorobenzene: Unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents
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A group of 1-[(2-hydroxyethoxy)methyl]- (12) and 1-[(1,3-dihydrdxy-2-propoxy)methyl]- (13) derivatives of 2,4-difluorobenzene possessing a variety of C-5 substituents (R = Me, H, I, NO2) were designed with the expectation that they may serve as
- Wang, Zhi-Xian,Duan, Weili,Wiebe, Leonard I.,De Clercq, Erik,Balzarini, Jan,Knaus, Edward E.
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p. 1397 - 1411
(2007/10/03)
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