Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists
Analogs 8-aza-16-aryl prostaglandin E1 (PGE1) and 8-aza-5-thia-16-arylPGE1 were synthesized and evaluated with respect to their subtype receptor affinity and EP4 agonist activity for the purposes of identifying sub-type- selective EP