- Biotransformation of imperatorin by Penicillium janthinellum. Anti-osteoporosis activities of its metabolites
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Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous fungi screened, Penicillium janthinellum AS 3.510 exhibited good capability to metabolise IMP to the new derivatives. Ten transformed products were isolated and purified, and their structures were identified accurately based on spectroscopic data. Eight metabolites (2-8 and 10) were novel and previously unreported. The major biotransformation reactions involved hydroxylation of the prenyloxy side-chain and the lactone ring-opening reaction of furocoumarin skeleton. In addition, anti-osteoporosis activities of all products (1-10) were evaluated using MC3T3-E1 cells. The results showed that products 5 and 8 had the best bioactivities in increasing MC3T3-E1 cell growth. These products could be used in future therapeutic regimens for treating osteoporosis.
- Lv, Xia,Liu, Dan,Hou, Jie,Dong, Peipei,Zhan, Libin,Wang, Li,Deng, Sa,Wang, Changyuan,Yao, Jihou,Shu, Xiaohong,Liu, Kexin,Ma, Xiaochi
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p. 2260 - 2266
(2013/06/04)
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- Two new coumarin derivatives from the roots of Heracleum rapula
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Two new coumarins, 13-O-[β-D-apiofuranosyl(1→6)-β-D- glucopyranosyl]-(12R)-heraclenol (1) and (12R,12″R)-diheraclenol (2) were isolated from the acetone extract of the fresh roots of Heracleum rapula. Their structures were determined by means of spectroscopic analysis and, in the case of compound 1, the structure elucidation was supported by acid hydrolysis. Compound 1 is a coumarin glycoside while 2 is a coumarin dimer. The inhibitory effects of 1, its aglycone (3), and 2 on rabbit platelet aggregation induced by PAF, AA and ADP were tested. Weak activities were observed for each compound with the percentages of inhibition in the range of 0.7-24.8%.
- Niu, Xue-Mei,Li, Sheng-Hong,Wu, Li-Xin,Li, Ling,Gao, Li-Hui,Sun, Han-Dong
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p. 578 - 581
(2007/10/03)
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- CHROMONES AND COUMARINS FROM SKIMMIA LAUREOLA
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The isolation and characterisation of chromones and coumarins, including the new chromone, skimminin, from S. laureola is reported. - Key Word Index: Skimmia laureola; Rutaceae; chromones; skimminin; coumarins; linear furanocoumarins.
- Razdan, T. K.,Qadri, B.,Harkar, S.,Waight, E. S.
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p. 2063 - 2070
(2007/10/02)
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