- Oxidation of psychotropic drugs by Chloramine-T in acid medium: A kinetic study using spectrophotometry
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The kinetics of oxidation of psychotropic drugs, chlorpromazine hydrochloride (CPH) and fluphenazine dihydrochloride (FPH), by Chloramine-T (CAT) in pH 1.6 buffer medium has been studied spectrophotometrically at λmax = 570 and 530 nm, respecti
- Saldanha,Ananda,Venkatesha,Made Gowda
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- Synthesis and molecular structure of zwitterionic complexes of phenothiazine-5-oxide derivatives coordinated with cobalt(II) and copper(II) ions
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The synthesis and characterization of Co(II)Cl2 and Cu(II)Cl2 complexes with 2-chloro-10-(3-dimethylaminopropyl)phenothiazine-5-oxide hydrochloride (epz(O)HCl) and three related compounds are described. The crystal structures of the complexes [CoCl3epz(O)H] (I) and [CuCl3 epz(O)H] (2) were determined by single-crystal X-ray diffraction analyses. I crystallizes in the monoclinic space group P21/c with a = 8.150(1), b = 17.763(2), c = 14.630(2) A, β = 103.93(1)°, V = 2055.8(3)A3, and Z = 4. 2 crystallizes in the monoclinic space group P21/c with a = 8.141(1), b = 17.175(4), c = 14.810(3)A, β = 103.27(1)°, V = 2015.5(7)A3 and Z = 4. The metal atoms in both complexes are coordinated in a tetrahedral geometry and the two complexes are arranged in a head-to-tail manner to form a dimer.
- Nakagawa,Chikuma,Li,Yamada,Kawazura
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- Mild and Selective Oxygenation of Sulfides to Sulfoxides and Sulfones by Perfluoro-cis-2,3-dialkyloxaziridines
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Sulfides are oxidized to sulfoxides by stoichiometric amounts of perfluoro-cis-2,3-dialkyloxaziridines 2.The reactions proceed at -40 deg C with nearly complete selectivity and very good yields.Sulfoxides are also oxidized easily by 2 under mild conditions to corresponding sulfones.The oxidation of some bioactive sulfides (promazine, albendazole, biotin, and others) is also reported.
- DesMarteau, Darryl D.,Petrov, Viacheslav A.,Montanari, Vittorio,Pregnolato, Massimo,Resnati, Giuseppe
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p. 2762 - 2765
(2007/10/02)
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