- TYK-2 INHIBITOR
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Disclosed herein is a compound of Formula (I) for inhibiting TYK2 and treating a disease associated with the undesirable tyk-2 activity (tyk-2 related diseases), a method of using the compounds disclosed herein for treating inflammatory or autoimmune disease, and a pharmaceutical composition comprising the same.
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- 2 Tyrosine kinase mediated signal transduction inhibitors
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Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.
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- Attachment of a RuII Complex to a Self-Folding Hexaamide Deep Cavitand
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We report the design, synthesis and characterization of a new RuII metallocavitand that is catalytically active in alkene epoxidation reactions. The elaboration of the resorcin[4]arene's aromatic cavity produced a self-folding, deep hexaamide cavitand featuring a single diverging terpyridine (tpy) group installed at its upper rim. The construction of the metallocavitand involved the initial chelation of a RuIII chloride complex by the tpy ligand followed by the incorporation of 2-(phenylazo)pyridine (azpy) as an ancillary ligand. The resulting RuII chloro complex was converted into the catalytically active aqua counterpart by a ligand exchange process.
- Korom, Sa?a,Ballester, Pablo
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p. 12109 - 12112
(2017/09/12)
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- An efficient and easy route to trimethyl derivatives of 2,2':6',2''-terpyridine
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By using the Stille coupling reaction, trimethyl derivatives of 2,2':6',2''-terpyridine have been prepared in good yields.
- Fallahpour
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p. 1665 - 1667
(2007/10/03)
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