Process development for sodelglitazar: A ppar panagonist
Three efficient syntheses of sodelglitazar (1) have been developed. In particular, the third synthesis avoids the use of zinc and eliminates the resulting heavy metal waste stream as well as the potential genotoxic methanesulfonate in the two earlier syntheses. This process produces sodelglitazar in 74% overall yield from readily available thiophenol (8) and thiazole alcohol (3).
Brown, Andrew D.,Davis, Roman D.,Fitzgerald, Russ N.,Glover, Bobby N.,Harvey, Kim A.,Jones, Lynda A.,Liu, Bing,Patterson, Daniel E.,Sharp, Matthew J.
experimental part
p. 297 - 302
(2010/04/22)
PROCESS FOR PREPARATION OF CHEMICAL COMPOUNDS
The present invention relates to a process for the preparation of certain chemical compounds. In particular, the present invention relates to a method for the preparation of compounds that have been shown to activate human peroxisome proliferator activate
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Page/Page column 34-35
(2010/02/07)
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