- Hydrazone-based derivative, intermediate, preparation method, pharmaceutical composition and applications thereof
-
The present invention discloses a hydrazone-based derivative (I), an intermediate, a preparation method, a pharmaceutical composition and applications thereof, wherein the hydrazone-based compound hasgood inhibitory effect on the ubiquitination activity of cIAP1 protein, can promote the degradation of oncogenic protein c-MYC at a cellular level so as to inhibit the growth of tumor cells, and hasbroad drug development prospects.
- -
-
Paragraph 0168-0172
(2019/10/01)
-
- Polymerizable compound, polymerizable composition, polymer, and optically anisotropic material
-
The present invention relates to: a polymerizable compound (I), wherein Y1 to Y6 are a chemical single bond, —O—C(═O)—, —C(═O)—O— or the like, G1 and G2 are a divalent aliphatic group, Z1 and Z2 are an alkenyl group, Ax is a fused ring group represented by a formula (II), wherein X is —NR3—, an oxygen atom, a sulfur atom or the like, R3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and D is a substituted or unsubstituted ring having 1 to 20 carbon atoms that includes at least one nitrogen atom, Ay is a hydrogen atom, an alkyl group, A1 is a trivalent aromatic group or the like, A2 and A3 are a divalent aromatic group having 6 to 30 carbon atoms or the like, and Q1 is a hydrogen atom, or an alkyl group having 1 to 6 carbon atoms.
- -
-
Page/Page column 35
(2016/12/26)
-
- POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND
-
A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article. A carbonyl compound is useful as a raw material for producing the polymerizable compound. (In the formula (I), Y1 to Y8 represent —C(═O)—O—, G1 and G2 represent a C1-20 divalent linear aliphatic group, Z1 and Z2 represent a C2-10 alkenyl group that is unsubstituted, or substituted with a halogen atom, Ax represents a C2-30 organic group with at least one aromatic ring, Ay represents a hydrogen atom or C1-20 alkyl group, A1 represents a trivalent aromatic group, A2 and A3 represent a C3-30 divalent alicyclic hydrocarbon group, A4 and A5 represent a C6-30 divalent aromatic group or the like, and Q1 represents a hydrogen atom.)
- -
-
Paragraph 0225; 0226; 0227; 0228
(2015/07/02)
-
- A new method for synthesizing asymmetric urea containing thiazolo[5,4-b]pyridine and applications in agriculture
-
Chemical Equation Presented In this article, we describe the use of diphenyl carbonate (DPC) as a carbonyl source instead of isocyanate to synthesize asymmetric substituted urea derivatives. In a study aiming to discover new lead compounds with agricultur
- Chen, Wenbin,Li, Kejian
-
experimental part
p. 311 - 318
(2011/04/16)
-
- A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas
-
(Chemical Equation Presented) A one-step synthesis of thiazolo[5,4-b] pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular, the reaction was used to prepare a large number of 6-nitrothiazo
- Sahasrabudhe, Kiran P.,Estiarte, M. Angels,Tan, Darlene,Zipfel, Sheila,Cox, Matthew,O'Mahony, Donogh J. R.,Edwards, William T.,Duncton, Matthew A. J.
-
experimental part
p. 1125 - 1131
(2010/03/01)
-
- Transformations of 1-(2-Chloropyridyl-3)-4-ethoxycarbonyl- and 1-(2-Chloropyridyl-3)-4-ethoxycarbonylmethyl Thiosemicarbazides. Attempts to Prepare Pyrido-1,2,4-thiadiazine
-
2-Chloro-3-hydrazinopyridine (2) was converted with ethoxycarbonyl and ethoxycarbonylmethyl isothiocyanates into 1,4-disubstituted thiosemicarbazides 3 and 4, while with phenyl isothiocyanate directly 1H-pyrido-1,3,4-thiadiazine 7 was formed.Attempts to cyclize the thiosemicarbazides 3 and 4 into pyridothiadiazine derivatives 5 and 6 failed.In the reaction of 3 with hydrazine 2-aminothiazolopyridine (9) was formed, while 4 gave only the corresponding hydrazide 10.The cyclization of the side chain occured in compound 4 by heating in aqueous hydrochloric acid to give 11, which was further transformed with N,N-dimethylformamide dimethyl acetal (DMFDMA) into 12, while with diethyl acetylene dicarboxylate the thiazolidone derivative 13 was produced. - Keywords: 1,4-Disubstituted thiosemicarbazides; 1H-Pyrido-1,3,4-thiadiazines; Thiazolidones
- Koren, Bozidar,Stanovnik, Branko,Tisler, Miha
-
p. 333 - 340
(2007/10/02)
-