- Method of asymmetric hydrogenation synthesis of chiral lactam by catalyzing 2-hydroxypyrazine compound with palladium
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The invention provides a method of asymmetric hydrogenation synthesis of chiral lactam by catalyzing 2-hydroxypyrazine compound with palladium. In the formula, R is a C1-C6 alkyl group or an aryl group containing a substituent group being at least one of F, Cl, Br, CF3, Me, MeO, Et and nPr. The method employs feasible raw materials and is high in enantioselectivity of product and high in yield, wherein the enantiomeric excess can reach 90%. The catalyst is low-cost and feasible and is good in air stability, so that the method is a route with good atom economy and environment-friendly effect for the asymmetric hydrogenation synthesis of the chiral lactam from the 2-hydroxypyrazine compound. Meanwhile, the method is simple in operation, is practicable and easy, is high in yield, is environment-friendly and green, is gentle in reaction conditions, and has a potential practical application value.
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Paragraph 0029-0045
(2020/03/17)
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- (1R,2R)-DPEN-derived triazolium salts for enantioselective oxodiene Diels-Alder reactions
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Enantioselective oxodiene Diels-Alder reactions catalyzed by (1R,2R)-DPEN-derived triazolium salts were realized successfully. With 0.5 mol % of (1R,2R)-DPEN-derived triazolium salt C and 150 mol % of Et3N, the reactions of various α-chloroalde
- Rong, Zi-Qiang,Jia, Min-Qiang,You, Shu-Li
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scheme or table
p. 9329 - 9333
(2011/12/14)
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- Synthesis of (1R,2R)-DPEN-derived triazolium salts and their application in asymmetric intramolecular Stetter reactions
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A series of novel chiral triazolium salts has been synthesized from readily available (1R,2R)-DPEN and found to be efficient for the enantioselective intramolecular Stetter reaction. With 10 mol% of the catalyst, the intramolecular Stetter reaction was re
- Jia, Min-Qiang,Li, Yi,Rong, Zi-Qiang,You, Shu-Li
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supporting information; experimental part
p. 2072 - 2074
(2011/05/14)
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