- INHIBITORS OF BETA-SECRETASE
-
The present invention relates to compounds represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
- -
-
Page/Page column 83
(2011/09/30)
-
- Total synthesis and complete structural assignment of thiocillin i
-
The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.
- Aulakh, Virender S.,Ciufolini, Marco A.
-
supporting information; experimental part
p. 5900 - 5904
(2011/06/10)
-
- An improved synthesis of pyridine-thiazole cores of thiopeptide antibiotics
-
(Figure Presented) The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.
- Aulakh, Virender S.,Ciufolini, Marco A.
-
supporting information; experimental part
p. 5750 - 5753
(2009/12/06)
-
- Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates
-
Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.
- Reiner, John E.,Siev, Daniel V.,Araldi, Gian-Luca,Cui, Jingrong Jean,Ho, Jonathan Z.,Reddy, Komandla Malla,Mamedova, Lala,Vu, Phong H.,Lee, Kuen-Shan S.,Minami, Nathaniel K.,Gibson, Tony S.,Anderson, Susanne M.,Bradbury, Annette E.,Nolan, Thomas G.,Semple, J. Edward
-
p. 1203 - 1208
(2007/10/03)
-