- COMPOUNDS AND USES THEREOF
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The present disclosure features compounds and methods useful for the treatment of BAF complex-related disorders.
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Page/Page column 177-178
(2021/08/06)
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- NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF
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The present disclosure relates to novel compounds having estrogen receptor alpha degradation activity, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.
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Paragraph 0589
(2020/06/08)
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- Substituted quinoline-8-carbonitrile derivatives having androgen receptor degradation activity and uses thereof
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The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions. In some embodiments, the compounds disclosed herein exhibit androgen receptor degradation activity.
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Page/Page column 73-74; 93-94
(2020/11/23)
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- Chroman derivatives having estrogen receptor degradation activity and uses thereof
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The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of cancer and related diseases and conditions.
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Page/Page column 101; 103; 104; 110
(2020/11/27)
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- Synthesis of 4-substituted phthalic anhydrides
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Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula STR1 The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula STR2 The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula STR3 where R1, R2, and R4 are preferably H and R3 is preferably Cl or F.
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- Method for the preparation of halophthalic anhydrides
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Halophthalic anhydrides are prepared by reaction of chlorine with a saturated or partially saturated halophthalic anhydride at a temperature of 200° to 500° Celsius.
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- Preparation of fluoroaromatic compounds in dispersion of potassium fluoride
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An improved process is disclosed for preparing fluoroaromatic compounds (such as fluoronitrobenzene compounds) wherein chloroaromatic compounds (such as chloronitrobenzene compounds) are reacted with potassium fluoride in a solvent dispersion thereof prepared from a mixture including the solvent, the fluoride, methanol and an aromatic compound.
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- Process for the preparation of 4-fluorophthalic anhydride
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This invention relates to a process for the preparation of 4-fluorophthalic anhydride which comprises contacting a dihalohexahydrophthalic anhydride of the formula STR1 where X is Cl or F, with a dehydrogenation catalyst. Advantageously, the process of the invention may be carried out in the presence of a hydrogen acceptor. The preferred hydrogen acceptor is a halocarbon hydrogen acceptor of the formula STR2 where Y is Cl, Br, or I; Z is Cl, Br or I; m is 0 to 4, n is 0 to 3, p is 0 to 3, and m+n is at least 1; with the proviso that when m is 0, p is at least 1.
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- Preparation of 4-fluorophthalic anhydride
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4-Fluorophthalic anhydride can be prepared by reacting potassium fluoride with 4-nitrophthalic anhydride. The use of solvents can increase the rate of reactivity and reduce the temperature at which reaction takes place. The more reactive 4-fluorophthalic anhydride can be used to make BPA-dianhydride employed in the production of polyetherimides.
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