- A convergent and flexible approach to hydroxylamines, hydrazines and related structures
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Intermolecular xanthate transfer radical addition to protected allyl hydroxylamine or hydrazine provides a new, flexible, and convergent route to adducts which can be readily elaborated into complex aromatic or heterocyclic hydroxylamine or hydrazine derivatives.
- Quiclet-Sire, Béatrice,Sortais, Beno?t,Zard, Samir Z.
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- PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS
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This invention is directed to a compound wherein R1, R2, R3, R4 and L1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the compound to treat allergic and/or
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Page/Page column 97-98
(2008/12/04)
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- Remedies for reperfusion injury containing integrin alphanubeta 3 antagonist
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An objective of the present invention is to provide an agent that is clinically effective in the treatment or prevention of reperfusion injury. The agent for use in the treatment or prevention of reperfusion injury according to the present invention comprises an integrin αvβ3 antagonist, a pharmaceutically acceptable salt thereof, or a solvate thereof as active ingredient.
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- 3-AMINOPIPERIDINE DERIVATIVES AS INTEGRIN γ(a)vγ(b)3 ANTAGONISTS
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An object of the present invention is to provide novel derivatives having integrin αvβ3 antagonistic activity wherein a basic atomic group has been attached to the 3-position of a piperidine ring either directly or through various atomic groups. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing at least one nitrogen atom, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; Z represents CH or N; R7 and R8 represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10 represents optionally substituted hydroxyl, amino or the like; R11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; p is 3 or 4; and q is 0 to 3.
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- m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM
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An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin αvβ3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR4, >CR5R6, O, S, or -NR4-CR5R6-; X represents CH or N; R7 and R8 represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R9 represents hydrogen, alkyl or the like; J represents a bond or alkylene; R10 represents optionally substituted hydroxyl, amino or the like; R11 represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.
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- Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation
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7-Oxabicycloheptane and prostaglandin analogs are provided having the structural formula STR1 and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
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- 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases
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7-Oxabicycloheptane hydrazone prostaglandin analogs are provided having the structural formula STR1 and including all stereoisomers thereof. pa The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
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