Palladium-catalyzed reactions of N-allylbenzotriazoles with amines and sulfonamides: A facile route to functionalized allylamines and N-allylsulfonamides
A variety of functionalized N-allylamines and N-allylsulfonamides are synthesized by Pd(II)- catalyzed intermolecular amination of the corresponding N-allylbenzotriazoles.
SYNTHESE DES MORPHOLINES. II. ALLYLATION CHIMIOSELECTIVE DES 2-AMINOALCOOLS, PRODUITS DE DEPART POUR LA FORMATION DES MORPHOLINES.
La reaction d'allylation des 2-aminoalcools est une reaction chimioselective donnant un acces facile et avec des bons rendements aux alcools correspondants exclusivement N-allyles.Leurs structures ont ete prouvees par spectrometrie de masse, IR et 1H RMN.
Dobrev, Alexandre,Spasov, Stefan,Lattes, Armand
p. 1601 - 1619
(2007/10/02)
Synthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics
A series of 2-(N-substituted amino)alkoxy-1,1-diphenylethanols was synthesized and evaluated for anticholinergic activity. The compounds differ structurally from the glycolate ester-type anticholinergic compounds by the bioisosteric substitution of a methylene group for the ester carbonyl moiety. The esters which result from this change have increased lipophilicity compared to their ester isosteres. Compounds in the series have significant anticholinergic activity when tested on isolated rat jejunum or for their ability to inhibit perphenazine-induced catatonia in rats. Structure-activity relationships of the compounds are discussed.
Fries,Andrako,Hudgins
p. 1250 - 1254
(2007/10/05)
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