- Intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as preparation method and application of intermediate compound
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The invention relates to an intermediate compound for preparing 4-chloro-2-trifluoromethyl-acetophenone as well as a preparation method and application of the intermediate compound. The intermediate compound is 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate, 3, 4-dimethylchlorobenzene is taken as an initial raw material, and the intermediate compound is obtained by chlorination, fluorine-chlorine exchange reaction, hydrolysis, continuous chlorination and coupling with malonate. The intermediate compound 2-(4-chloro-2-(trifluoromethyl) benzoyl) malonate is subjected to hydrolysis decarboxylation to obtain 4-chloro-2-trifluoromethyl-acetophenone, the raw materials in the route are easy to obtain, dangerous reactions such as nitration and Grignard reaction are avoided, and the method is suitable for industrial production.
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- 2-benzoyl malonate compound as well as preparation method and application thereof
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The invention discloses a 2-benzoyl malonate compound as well as a preparation method and application thereof. The invention provides a preparation method of an acetylbenzene compound shown as a formula III. The preparation method comprises the following step: in an organic solvent, in the presence of an acid and water, carrying out a deesterification reaction as shown in the specification on a 2-benzoyl malonate compound as shown in a formula I and/or a tautomer thereof to obtain the acetylbenzene compound as shown in a formula III, wherein X is F, Cl, Br or I; wherein R1 and R2 are each independently a C1-C4 alkyl group. By adopting the 2-benzoyl malonate compound disclosed by the invention, 4-halogenated-2-trifluoromethyl acetophenone can be prepared through one-step reaction, and the operation is simple and convenient.
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Paragraph 0098-0101
(2020/07/15)
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- Preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and intermediate of o-trifluoromethyl-4-halogenobenzaldehyde
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The invention discloses a preparation method of o-trifluoromethyl-4-halogenobenzaldehyde and an intermediate of the o-trifluoromethyl-4-halogenobenzaldehyde. The preparation method comprises that under solvent-free conditions, in the presence of an acid a
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- 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS
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The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.
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Page/Page column 63
(2010/11/08)
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