- Enantioselective construction of the oxidized tryptophan fragment of proteasome inhibitors TMC-95A and TMC-95B
-
The oxidized tryptophan analogue 5, a proposed intermediate for a synthesis of the proteasome inhibitors TMC-95A and TMC-95B, is prepared using the condensation of oxindole 7 with the (R)-Garner aldehyde and stereoselective dihydroxylation of olefin 6 as key steps. (C) 2000 Elsevier Science Ltd.
- Ma,Wu
-
-
Read Online
- Functionalization at Nonperipheral Positions of Triazatruxene: Modular Construction of 1,6,11-Triarylated-Triazatruxenes for Potentially Organic Electronics and Optoelectronics
-
Functionalization from nonperipheral positions of triazatruxene is representing a challenge. Triarylation of the nonperipheral positions (1, 6, and 11) in triazatruxene scaffold has been achieved for the first time via two approaches. The transformations involve arylation/cyclotrimerization and cyclotrimerization/arylation sequences. POCl3-mediated direct cyclotrimerization of oxindoles containing electron-deficient substituents on the aryl group at the C7-position resulted in the formation of 2-chloroindoles, whereas oxindoles containing electron-donating substituents gave the triazatruxenes. Furthermore, desired triazatruxenes were achieved through cyclotrimerization of 7-bromooxindole followed by coupling with arylboronic acids. NMR structural analysis exhibited that two of the suitably substituted oxindole and triazatuxene may have atropisomerism at room temperature. As a representative triazatruxene scaffold, the optoelectronic properties of 9a have also been studied via ultraviolet-visible (UV-vis) absorption spectra and fluorescence spectra of 9a thin films. Also, density functional theory calculation was realized to get knowledge about frontier molecular orbitals. In the light of the information obtained, an organic light-emitting diode (OLED) device utilizing 9a as an emissive layer was applied to obtain white emission. In brief, this study provides the first examples of the synthesis of triazatruxenes bearing aryl substituents at the nonperipheral positions as candidate compounds for organic electronics, optoelectronics, and material chemistry.
- Aslan, Murat,Plravadlll, Selin,Saracoglu, Nurullah,Taskesenligil, Yunus
-
-
- HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION
-
The present disclosure relates to compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis.and characterization of aforementioned substances.
- -
-
-
- Synthesis of novel 3-(benzothiazol-2-ylmethylene)indolin-2-ones
-
A mild method for the synthesis of 3-(benzothiazol-2-ylmethylene)indolin-2-ones via the aldol condensation of substituted indolin-2-ones and benzothiazole-2-carbaldehyde is described. This new procedure has significant advantages, such as mild conditions, high yields and simple work-up.
- Zhang, Chao,Xu, Juan,Zhao, Xinyu,Kang, Congmin
-
p. 537 - 540
(2017/10/03)
-
- Selective reduction of carbonyl groups in the presence of low-valent titanium reagents
-
The chemoselective reduction of several structurally diverse compounds containing carbonyl groups was achieved in the presence of low-valent titanium reagents. This novel synthetic method provides easy access to highly selective reduction of carbonyl groups, and possesses several advantages including one-step procedure, convenient manipulation, good to excellent yields, and short reaction times.
- Lin, Wei,Hu, Ming-Hua,Feng, Xian,Fu, Lei,Cao, Cheng-Pao,Huang, Zhi-Bin,Shi, Da-Qing
-
p. 2238 - 2242
(2014/04/17)
-
- Heterocyclic sulfonamide derivatives
-
The present invention provides certain heterocyclic sulfonamide derivatives of formula (I): useful for potentiating glutamate receptor function in a patient and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
- -
-
Page 14 - 15
(2010/11/29)
-
