- One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization
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A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.
- Yang, Dejun,Zhu, Yifei,Yang, Na,Jiang, Qiangqiang,Liu, Renhua
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supporting information
p. 1731 - 1735
(2016/06/09)
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- PROCESS FOR THE PREPARATION 3,5-BIS(TRIFLUOROMETHYL)BENZYLALCOHOL
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The present invention concerns a process for preparing 3,5bis(trifluoromethyl)benzylalcohol by formylation in a solvent of an appropriate organo-magnesium derivative with solid paraformaldehyde and optionally its conversion into a 3,5-bis(trifluoromethyl)benzyl halide.
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Page/Page column 7-8
(2010/02/11)
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- N-acylamino benzyl ether derivatives
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This invention relates to N-acylamino aryl derivatives of the formula 1where R1, R21, R22, R23, R3, R4, R5 R6, R7, R8, R, and n are as defined herein and where X is —CHRO, —OCHR—, —CH2S—, —SCH2—, —CH2CH2—, —CH=CH— or —C≡C—. The compounds of the invention are selective monoamine oxidase B inhibitors, and they are therefore useful in the treatment of diseases mediated by monoamine oxidase B, for example, for the treatment of Alzheimer's disease or senile dementia.
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- Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds
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This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
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- 2-OXABICYCLO(2,2,1)HEPTANE DERIVATIVES AND PHARMACEUTICAL
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The invention relates to 2-oxabicyclo[2.2.1]heptane derivatives of formula I (I) as well as their enantiomers, in which, e.g., A means -(CH2)n-, (E)- or (Z)-CH=CH-, -C 3BOND C, -O- or -S-, B means hydrogen, C1-C10 alkyl, -OR2, halogen, -C 3BOND N, -N3, -COOR3, R1 means oxygen or a -CH2 group, Z means -(CH2)p-, (E)-CH=CH-, -C 3BOND C-, W means a direct bond, a free or functionally modified hydroxymethylene group or a free or functionally modified in which the OH group can be respectively in alpha- or beta-position, D means a direct bond, a saturated alkylene group with 1-5 C atoms, a branched saturated or a straight-chain of branched unsaturated alkylene group with 2-5 C atoms, E means a direct bond, -C 3BOND C- or -CH=CR7, R8 means hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl, optionally substituted C6-C12 aryl or a 5- or 6-member heterocyclic radical, and if R5 means hydrogen, their salts with physiologically compatible bases, as well as the alpha-, beta- or gamma-cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and the pharmaceutical agents containing these compounds. The compounds are thromboxane antagonists
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